VAPA

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]

Full Name

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

Function

Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204).
The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204).
With OSBPL3, may regulate ER morphology (PubMed:16143324).
May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470).

Biological Process

Biological Process cell death Source:UniProtKB1 Publication
Biological Process ceramide transport Source:ComplexPortal1 Publication
Biological Process COPII-coated vesicle budding Source:UniProtKB1 Publication
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKB1 Publication
Biological Process membrane fusion Source:ProtInc1 Publication
Biological Process negative regulation by host of viral genome replication Source:AgBase1 Publication
Biological Process neuron projection development Source:UniProtKB1 Publication
Biological Process phospholipid transport Source:ComplexPortal1 Publication
Biological Process positive regulation by host of viral genome replication Source:AgBase1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process protein localization to endoplasmic reticulum Source:UniProtKB1 Publication
Biological Process sphingomyelin biosynthetic process Source:ComplexPortal1 Publication
Biological Process sterol transport Source:ComplexPortal1 Publication
Biological Process viral release from host cell Source:AgBase1 Publication

Cellular Location

Endoplasmic reticulum membrane
Cell membrane
Cell junction, tight junction
Nucleus membrane
Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells.

Topology

Cytoplasmic: 2-227
Helical: 228-248