Mouse Anti-VASH1 Recombinant Antibody (CBYY-1261) (CBMAB-1269-YY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830).
Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325).
This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096).
Biological Process cell cycle Source:UniProtKB-KW
Biological Process labyrinthine layer blood vessel development Source:Ensembl
Biological Process negative regulation of angiogenesis Source:UniProtKB1 Publication
Biological Process negative regulation of blood vessel endothelial cell migration Source:UniProtKB1 Publication
Biological Process negative regulation of endothelial cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of lymphangiogenesis Source:MGI2 Publications
Biological Process proteolysis Source:UniProtKB1 Publication
Biological Process regulation of angiogenesis Source:GO_Central1 Publication
Biological Process regulation of cell cycle Source:UniProtKB-KW
Biological Process regulation of cellular senescence Source:MGI1 Publication
Biological Process response to wounding Source:MGI1 Publication
Secreted
Mainly localizes in the cytoplasm (PubMed:27879017).
Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:27879017).
The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu (PubMed:16488400).
Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form (PubMed:16488400).
Ubiquitinated in vitro.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
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Mouse Anti-VASH1 Recombinant Antibody (CBYY-1262) (CAT#: CBMAB-1270-YY)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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