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Rabbit Anti-VASH1 Recombinant Antibody (CBYY-1264) (CBMAB-1272-YY)

This product is rabbit antibody that recognizes VASH1. The antibody CBYY-1264 can be used for immunoassay techniques such as: WB, IP, IF
See all VASH1 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBYY-1264
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
vasohibin 1
Introduction
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human22846
Mouse238328
Rat503052
UniProt ID
HumanQ7L8A9
MouseQ8C1W1
RatD4AE85
Alternative Names
WAS Protein Family Member 1; Verprolin Homology Domain-Containing Protein 1; WASP Family Protein Member 1; Protein WAVE-1; SCAR1; WAVE1;
Function
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869, PubMed:31270470, PubMed:31235910, PubMed:31171830, PubMed:31235911).
Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830).
Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325).
This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096).
Biological Process
Biological Process angiogenesis Source:MGI1 Publication
Biological Process cell cycle Source:UniProtKB-KW
Biological Process labyrinthine layer blood vessel development Source:Ensembl
Biological Process negative regulation of angiogenesis Source:UniProtKB1 Publication
Biological Process negative regulation of blood vessel endothelial cell migration Source:UniProtKB1 Publication
Biological Process negative regulation of endothelial cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of lymphangiogenesis Source:MGI2 Publications
Biological Process proteolysis Source:UniProtKB1 Publication
Biological Process regulation of angiogenesis Source:GO_Central1 Publication
Biological Process regulation of cell cycle Source:UniProtKB-KW
Biological Process regulation of cellular senescence Source:MGI1 Publication
Biological Process response to wounding Source:MGI1 Publication
Cellular Location
Cytoplasm
Secreted
Mainly localizes in the cytoplasm (PubMed:27879017).
Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:27879017).
PTM
2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage (PubMed:16488400).
The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu (PubMed:16488400).
Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form (PubMed:16488400).
Ubiquitinated in vitro.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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