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Rabbit Anti-VAV1 Recombinant Antibody (CBYY-1300) (CBMAB-1319-YY)

This product is rabbit antibody that recognizes VAV1. The antibody CBYY-1300 can be used for immunoassay techniques such as: WB, IP
See all VAV1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
CBYY-1300
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
VAV1
Introduction
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforMouse have been observed for this gene.
Entrez Gene ID
Human7409
Monkey100424246
UniProt ID
HumanP15498
MonkeyH9Z2E1
Alternative Names
Vav Guanine Nucleotide Exchange Factor 1; Vav 1 Guanine Nucleotide Exchange Factor; Vav 1 Oncogene; VAV; Proto-Oncogene Vav;
Function
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Biological Process
Biological Process cell migration Source:GO_Central1 Publication
Biological Process cellular response to xenobiotic stimulus Source:Reactome
Biological Process Fc-epsilon receptor signaling pathway Source:Reactome
Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis Source:Reactome
Biological Process G protein-coupled receptor signaling pathway Source:Ensembl
Biological Process immune response Source:Ensembl
Biological Process integrin-mediated signaling pathway Source:Ensembl
Biological Process neutrophil chemotaxis Source:Ensembl
Biological Process platelet activation Source:Reactome
Biological Process positive regulation of GTPase activity Source:Ensembl
Biological Process positive regulation of natural killer cell mediated cytotoxicity Source:Ensembl
Biological Process reactive oxygen species metabolic process Source:Ensembl
Biological Process regulation of cell size Source:UniProtKB1 Publication
Biological Process regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process regulation of small GTPase mediated signal transduction Source:Reactome
Biological Process small GTPase mediated signal transduction Source:InterPro
Biological Process T cell costimulation Source:Reactome
Biological Process T cell differentiation Source:Ensembl
Biological Process vascular endothelial growth factor receptor signaling pathway Source:Reactome
Cellular Location
cell-cell junction
cytoplasm
cytosol
plasma membrane
PTM
Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity).
Phosphorylated by FYN.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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