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VAV1

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Full Name
VAV1
Function
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Biological Process
Biological Process cell migration Source:GO_Central1 Publication
Biological Process cellular response to xenobiotic stimulus Source:Reactome
Biological Process Fc-epsilon receptor signaling pathway Source:Reactome
Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis Source:Reactome
Biological Process G protein-coupled receptor signaling pathway Source:Ensembl
Biological Process immune response Source:Ensembl
Biological Process integrin-mediated signaling pathway Source:Ensembl
Biological Process neutrophil chemotaxis Source:Ensembl
Biological Process platelet activation Source:Reactome
Biological Process positive regulation of GTPase activity Source:Ensembl
Biological Process positive regulation of natural killer cell mediated cytotoxicity Source:Ensembl
Biological Process reactive oxygen species metabolic process Source:Ensembl
Biological Process regulation of cell size Source:UniProtKB1 Publication
Biological Process regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process regulation of small GTPase mediated signal transduction Source:Reactome
Biological Process small GTPase mediated signal transduction Source:InterPro
Biological Process T cell costimulation Source:Reactome
Biological Process T cell differentiation Source:Ensembl
Biological Process vascular endothelial growth factor receptor signaling pathway Source:Reactome
Cellular Location
cell-cell junction
cytoplasm
cytosol
plasma membrane
PTM
Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity).
Phosphorylated by FYN.
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Anti-VAV1 antibodies

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Mouse Anti-VAV1 Antibody (14F7) (CBMAB-1798CQ)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14F7
Application*: E, M
Datasheet SDS

Recombinant Mouse Anti-VAV1 Antibody (CBAb242) (CBMAB-Ab242-LY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb242
Application*: WB
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (9C1) (CBMAB-A9860-LY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 9C1
Application*: WB, E
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (3A11) (CBMAB-A9859-LY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3A11
Application*: WB, E
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (2C11) (CBMAB-A9858-LY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2C11
Application*: WB, E
Datasheet SDS

Mouse Anti-Vav1 Recombinant Antibody (5E7-F8-B9) (CBMAB-Z0175-LY)

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Target: Vav1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E7-F8-B9
Application*: WB, F
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1560) (CBMAB-1630-YY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: CBYY-1560
Application*: WB
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1559) (CBMAB-1629-YY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1559
Application*: E, WB, F
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1558) (CBMAB-1628-YY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1558
Application*: WB
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1557) (CBMAB-1627-YY)

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Target: VAV1
Host: Mouse
Specificity: Human
Clone: CBYY-1557
Application*: WB
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1893) (CBMAB-1625-YY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-1893
Application*: SE, E, WB-Re, WB-Ce
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1303) (CBMAB-1322-YY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1303
Application*: E, WB
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1302) (CBMAB-1321-YY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1302
Application*: WB
Datasheet SDS

Rabbit Anti-VAV1 Recombinant Antibody (CBYY-1300) (CBMAB-1319-YY)

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Target: VAV1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBYY-1300
Application*: WB, IP
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1299) (CBMAB-1318-YY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-1299
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1297) (CBMAB-1315-YY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-1297
Application*: E, WB
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1296) (CBMAB-1314-YY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYY-1296
Application*: WB
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1295) (CBMAB-1313-YY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1295
Application*: WB
Datasheet SDS

Rabbit Anti-VAV1 Recombinant Antibody (CBYY-1294) (CBMAB-1312-YY)

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Target: VAV1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-1294
Application*: WB, IP, F, IF
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBYY-1892) (CBMAB-1311-YY)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1892
Application*: E, F, WB
Datasheet SDS

Mouse Anti-VAV1 Antibody (7F12) (CBMAB-1801CQ)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7F12
Application*: E, M
Datasheet SDS

Mouse Anti-VAV1 Antibody (5F1) (CBMAB-1800CQ)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5F1
Application*: E, M
Datasheet SDS

Mouse Anti-VAV1 Antibody (1F4) (CBMAB-1799CQ)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1F4
Application*: E, M
Datasheet SDS

Mouse Anti-VAV1 Antibody (11F7) (CBMAB-1797CQ)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11F7
Application*: E, M
Datasheet SDS

Mouse Anti-VAV1 Antibody (11C11) (CBMAB-1796CQ)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11C11
Application*: E, M
Datasheet SDS

Mouse Anti-VAV1 Antibody (10C11) (CBMAB-1795CQ)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 10C11
Application*: E, M
Datasheet SDS

Mouse Anti-VAV1 Recombinant Antibody (CBT2621) (V2LY-0625-LY2738)

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Target: VAV1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2621
Application*: WB, F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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