Rat Anti-VCAM1 Recombinant Antibody (6C7.1) (CBMAB-X0084-FY)

Vascular Cell Adhesion Molecule 1

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.

CD106; Vcam-1

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Biological Process acute inflammatory response Source:Ensembl
Biological Process aging Source:Ensembl
Biological Process amine metabolic process Source:UniProtKB1 Publication
Biological Process B cell differentiation Source:BHF-UCL1 Publication
Biological Process calcium-mediated signaling using intracellular calcium Source Source:UniProtKB1 Publication
Biological Process cardiac neuron differentiation Source:Ensembl
Biological Process cell adhesion Source:BHF-UCL1 Publication
Biological Process cell chemotaxis Source:Ensembl
Biological Process cell-cell adhesion in response to extracellular stimulus Source:ARUK-UCL1 Publication
Biological Process cell-matrix adhesion Source:UniProtKB1 Publication
Biological Process cellular response to amyloid-beta Source:ARUK-UCL1 Publication
Biological Process cellular response to tumor necrosis factor Source:Ensembl
Biological Process cellular response to vascular endothelial growth factor stimulus Source:Ensembl
Biological Process chronic inflammatory response Source:Ensembl
Biological Process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source:BHF-UCL1 Publication
Biological Process heterotypic cell-cell adhesion Source:ARUK-UCL1 Publication
Biological Process innervation Source:Ensembl
Biological Process leukocyte cell-cell adhesion Source:BHF-UCL3 Publications
Biological Process leukocyte tethering or rolling Source:UniProtKB1 Publication
Biological Process membrane to membrane docking Source:BHF-UCL1 Publication
Biological Process positive regulation of T cell proliferation Source:BHF-UCL1 Publication
Biological Process response to ethanol Source:Ensembl
Biological Process response to hypoxia Source:Ensembl
Biological Process response to ionizing radiation Source:Ensembl
Biological Process response to lipopolysaccharide Source:Ensembl
Biological Process response to nicotine Source:Ensembl
Biological Process response to nutrient Source:Ensembl
Biological Process response to zinc ion Source:Ensembl

Membrane

Extracellular: 25-698
Helical: 699-720
Cytoplasmic: 721-739

Sialoglycoprotein.