Sign in or Register   Sign in or Register
  |  

Mouse Anti-VDAC2 Recombinant Antibody (3D2) (CBMAB-A9873-LY)

The product is antibody recognizes VDAC2. The antibody 3D2 immunoassay techniques such as: WB, ELISA.
See all VDAC2 antibodies
Published Data
Fig.1 Ubiquitination of the Parkin substrate VDAC1 in ATO-treated HL-1 cells.
...View More

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
3D2
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
VDAC2 (AAH00165, 1 a.a. ~ 294 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
voltage-dependent anion channel 2
Entrez Gene ID
Human7417
Rat83531
UniProt ID
HumanP45880
RatP81155
Alternative Names
FLJ23841
Function
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity).
The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity).
The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).
Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432).
Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432).
Biological Process
Biological Process anion transport Source:UniProtKB1 Publication
Biological Process binding of sperm to zona pellucida Source:CAFA1 Publication
Biological Process mitochondrial outer membrane permeabilization Source:UniProtKB1 Publication
Biological Process negative regulation of intrinsic apoptotic signaling pathway Source:Ensembl
Biological Process negative regulation of protein polymerization Source:Ensembl
Cellular Location
Mitochondrion outer membrane
Membrane
May localize to non-mitochondrial membranes.
PTM
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-VDAC2 Recombinant Antibody (3D2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare