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Mouse Anti-VDAC2 Recombinant Antibody (CBYY-1398) (CBMAB-1446-YY)

This product is mouse antibody that recognizes VDAC2. The antibody CBYY-1398 can be used for immunoassay techniques such as: ELISA, WB
See all VDAC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1398
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-294 from human VDAC2 (AAH00165) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
voltage-dependent anion channel 2
Introduction
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants.
Entrez Gene ID
7417
UniProt ID
P45880
Alternative Names
Voltage Dependent Anion Channel 2; Outer Mitochondrial Membrane Protein Porin 2; Voltage-Dependent Anion-Selective Channel Protein 2; VDAC-2; HVDAC2; POR;
Function
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity).
The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity).
The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).
Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432).
Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432).
Biological Process
Biological Process anion transport Source:UniProtKB1 Publication
Biological Process binding of sperm to zona pellucida Source:CAFA1 Publication
Biological Process mitochondrial outer membrane permeabilization Source:UniProtKB1 Publication
Biological Process negative regulation of intrinsic apoptotic signaling pathway Source:Ensembl
Biological Process negative regulation of protein polymerization Source:Ensembl
Cellular Location
Mitochondrion outer membrane
Membrane
May localize to non-mitochondrial membranes.
PTM
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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