Mouse Anti-VEGFA Recombinant Antibody (CBT2168) (V2LY-0625-LY434)

Mouse

Human

CBT2168

IgG1

WB, ICC

Purified recombinant fragment of human VEGFA (AA: 207-371) expressed in E. Coli.

Mouse

Human

IgG1

Monoclonal Antibody

Liquid

PBS

Sodium azide

Batch dependent

> 95% Purity determined by SDS-PAGE.

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Vascular Endothelial Growth Factor A

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437).

Biological Process activation of protein kinase activity Source:BHF-UCL2 Publications
Biological Process angiogenesis Source:UniProtKB2 Publications
Biological Process artery morphogenesis Source:BHF-UCL
Biological Process basophil chemotaxis Source:UniProtKB
Biological Process branching involved in blood vessel morphogenesis Source:BHF-UCL2 Publications
Biological Process camera-type eye morphogenesis Source:BHF-UCL
Biological Process cardiac muscle cell development Source:BHF-UCL
Biological Process cardiac vascular smooth muscle cell development Source:BHF-UCL
Biological Process cell maturation Source:BHF-UCL
Biological Process cell migration involved in sprouting angiogenesis Source:BHF-UCL2 Publications
Biological Process cellular response to hypoxia Source:MGI1 Publication
Biological Process cellular response to vascular endothelial growth factor stimulus Source:BHF-UCL2 Publications
Biological Process cellular stress response to acid chemical Source:BHF-UCL1 Publication
Biological Process commissural neuron axon guidance Source:BHF-UCL
Biological Process coronary artery morphogenesis Source:BHF-UCL
Biological Process coronary vein morphogenesis Source:BHF-UCL
Biological Process dopaminergic neuron differentiation Source:BHF-UCL
Biological Process endothelial cell chemotaxis Source:BHF-UCL1 Publication
Biological Process epithelial cell differentiation Source:BHF-UCL
Biological Process eye photoreceptor cell development Source:BHF-UCL
Biological Process heart morphogenesis Source:BHF-UCL
Biological Process in utero embryonic development Source:BHF-UCL
Biological Process induction of positive chemotaxis Source:UniProtKB1 Publication
Biological Process kidney development Source:BHF-UCL
Biological Process lactation Source:BHF-UCL
Biological Process lung development Source:BHF-UCL
Biological Process lymph vessel morphogenesis Source:BHF-UCL
Biological Process macrophage differentiation Source:DFLAT1 Publication
Biological Process mammary gland alveolus development Source:BHF-UCL
Biological Process mesoderm development Source:BHF-UCL
Biological Process monocyte differentiation Source:DFLAT1 Publication
Biological Process motor neuron migration Source:UniProtKB
Biological Process negative regulation of adherens junction organization Source:ARUK-UCL1 Publication
Biological Process negative regulation of apoptotic process Source:UniProtKB2 Publications
Biological Process negative regulation of blood-brain barrier permeability Source:ARUK-UCL1 Publication
Biological Process negative regulation of cell-cell adhesion mediated by cadherin Source:ARUK-UCL1 Publication
Biological Process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of establishment of endothelial barrier Source:ARUK-UCL1 Publication
Biological Process negative regulation of gene expression Source:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process nervous system development Source:UniProtKB1 Publication
Biological Process outflow tract morphogenesis Source:BHF-UCL
Biological Process ovarian follicle development Source:BHF-UCL
Biological Process positive chemotaxis Source:BHF-UCL1 Publication
Biological Process positive regulation of angiogenesis Source:BHF-UCL1 Publication
Biological Process positive regulation of axon extension involved in axon guidance Source:BHF-UCL
Biological Process positive regulation of blood vessel endothelial cell migration Source:BHF-UCL3 Publications
Biological Process positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source:ARUK-UCL1 Publication
Biological Process positive regulation of branching involved in ureteric bud morphogenesis Source:BHF-UCL
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of cell division Source:UniProtKB-KW
Biological Process positive regulation of cell migration Source:BHF-UCL2 Publications
Biological Process positive regulation of cell migration by vascular endothelial growth factor signaling pathway Source:BHF-UCL
Biological Process positive regulation of cell migration involved in sprouting angiogenesis Source:BHF-UCL1 Publication
Biological Process positive regulation of cell population proliferation Source:BHF-UCL1 Publication
Biological Process positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway Source:BHF-UCL1 Publication
Biological Process positive regulation of cold-induced thermogenesis Source:YuBioLabBy Similarity
Biological Process positive regulation of CREB transcription factor activity Source:BHF-UCL1 Publication
Biological Process positive regulation of DNA biosynthetic process Source:UniProtKB
Biological Process positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Source:BHF-UCL3 Publications
Biological Process positive regulation of endothelial cell migration Source:BHF-UCL1 Publication
Biological Process positive regulation of endothelial cell proliferation Source:BHF-UCL2 Publications
Biological Process positive regulation of epithelial cell proliferation Source:BHF-UCL
Biological Process positive regulation of epithelial tube formation Source:BHF-UCL
Biological Process positive regulation of ERK1 and ERK2 cascade Source:BHF-UCL
Biological Process positive regulation of focal adhesion assembly Source:UniProtKB1 Publication
Biological Process positive regulation of gene expression Source:BHF-UCL1 Publication
Biological Process positive regulation of histone deacetylase activity Source:BHF-UCL1 Publication
Biological Process positive regulation of leukocyte migration Source:BHF-UCL1 Publication
Biological Process positive regulation of MAP kinase activity Source:BHF-UCL1 Publication
Biological Process positive regulation of MAPK cascade Source:BHF-UCL
Biological Process positive regulation of mast cell chemotaxis Source:UniProtKB1 Publication
Biological Process positive regulation of neuroblast proliferation Source:BHF-UCL
Biological Process positive regulation of p38MAPK cascade Source:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-serine phosphorylation Source:BHF-UCL2 Publications
Biological Process positive regulation of peptidyl-tyrosine autophosphorylation Source:BHF-UCL1 Publication
Biological Process positive regulation of peptidyl-tyrosine phosphorylation Source:BHF-UCL1 Publication
Biological Process positive regulation of phosphatidylinositol 3-kinase signaling Source:BHF-UCL
Biological Process positive regulation of phosphorylation Source:BHF-UCL
Biological Process positive regulation of positive chemotaxis Source:BHF-UCL2 Publications
Biological Process positive regulation of protein autophosphorylation Source:BHF-UCL1 Publication
Biological Process positive regulation of protein kinase B signaling Source:BHF-UCL
Biological Process positive regulation of protein kinase C signaling Source:BHF-UCL1 Publication
Biological Process positive regulation of protein kinase D signaling Source:BHF-UCL1 Publication
Biological Process positive regulation of protein localization to early endosome Source:BHF-UCL
Biological Process positive regulation of protein phosphorylation Source:UniProtKB2 Publications
Biological Process positive regulation of protein-containing complex assembly Source:UniProtKB2 Publications
Biological Process positive regulation of receptor internalization Source:BHF-UCL1 Publication
Biological Process positive regulation of retinal ganglion cell axon guidance Source:BHF-UCL
Biological Process positive regulation of sprouting angiogenesis Source:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Source:BHF-UCL1 Publication
Biological Process positive regulation of trophoblast cell migration Source:BHF-UCL1 Publication
Biological Process positive regulation of vascular endothelial growth factor signaling pathway Source:ComplexPortal1 Publication
Biological Process positive regulation of vascular permeability Source:ARUK-UCL1 Publication
Biological Process post-embryonic camera-type eye development Source:BHF-UCL
Biological Process primitive erythrocyte differentiation Source:BHF-UCL
Biological Process regulation of cell shape Source:BHF-UCL2 Publications
Biological Process regulation of nitric oxide mediated signal transduction Source:MGI1 Publication
Biological Process regulation of retinal ganglion cell axon guidance Source:BHF-UCL
Biological Process regulation of transcription by RNA polymerase II Source:BHF-UCL
Biological Process response to hypoxia Source:UniProtKB1 Publication
Biological Process sprouting angiogenesis Source:GO_Central1 Publication
Biological Process surfactant homeostasis Source:BHF-UCL
Biological Process tube formation Source:UniProtKB1 Publication
Biological Process vascular endothelial growth factor receptor signaling pathway Source:BHF-UCL3 Publications
Biological Process vascular endothelial growth factor receptor-2 signaling pathway Source:BHF-UCL1 Publication
Biological Process vascular endothelial growth factor signaling pathway Source:UniProtKB1 Publication
Biological Process vascular wound healing Source:BHF-UCL1 Publication
Biological Process vasculogenesis Source:UniProtKB1 Publication
Biological Process VEGF-activated neuropilin signaling pathway Source:BHF-UCL

Secreted
VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.

Microvascular complications of diabetes 1 (MVCD1):
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.