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Rabbit Anti-VNN2 Recombinant Antibody (CBXF-3504) (CBMAB-F1173-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXF-3504
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant Human VNN2/Vanin-2 protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Vanin 2
Introduction
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Entrez Gene ID
8875
UniProt ID
O95498
Alternative Names
Vanin 2; Glycosylphosphatidyl Inositol-Anchored Protein GPI-80; Pantetheinase; EC 3.5.1.92; Vascular Non-Inflammatory Molecule 2; Protein FOAP-4;
Function
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine (PubMed:11491533).
Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.
Biological Process
Biological Process pantothenate metabolic process Source:BHF-UCL1 Publication
Cellular Location
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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