VNN2

This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Full Name
Vanin 2
Function
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine (PubMed:11491533).
Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.
Biological Process
Biological Process pantothenate metabolic process Source:BHF-UCL1 Publication
Cellular Location
Cell membrane
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Anti-VNN2 antibodies

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Mouse Anti-VNN2 Recombinant Antibody (3H9) (CBMAB-V0021-LY)

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Target: VNN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H9
Application*: F, WB
Datasheet SDS

Mouse Anti-VNN2 Recombinant Antibody (CBXF-2040) (CBMAB-F1360-CQ)

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Target: VNN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2040
Application*: E, WB
Datasheet SDS

Rabbit Anti-VNN2 Recombinant Antibody (CBXF-3504) (CBMAB-F1173-CQ)

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Target: VNN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3504
Application*: E, WB
Datasheet SDS

Mouse Anti-VNN2 Recombinant Antibody (CBYY-2044) (CBMAB-1592-YY)

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Target: VNN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-2044
Application*: F, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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