Mouse Anti-VPS39 Recombinant Antibody (C-5) (CBMAB-V0049-YC)

Name: Mouse Anti-VPS39 Recombinant Antibody (C-5)
SKU: CBMAB-V0049-YC
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

C-5

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

VPS39, HOPS Complex Subunit

Introduction

VPS39 may promote clustering and fusion of late endosomes and lysosomes. VPS39 may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway.

Entrez Gene ID

23339

UniProt ID

Q96JC1

Alternative Names

VPS39, HOPS Complex Subunit; TRAP1-Like Protein; HVam6p; VAM6; TLP; Vacuolar Protein Sorting 39 Homolog (S. Cerevisiae)

Function

Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation.
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085).
Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (PubMed:11448994, PubMed:23351085, PubMed:23167963).
Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203).

Biological Process

Biological Process autophagosome-lysosome fusion Source:UniProtKB1 Publication
Biological Process autophagy Source:UniProtKB1 Publication
Biological Process endocytic recycling Source:UniProtKB1 Publication
Biological Process endosomal vesicle fusion Source:UniProtKB1 Publication
Biological Process endosome to lysosome transport Source:UniProtKB2 Publications
Biological Process intracellular protein transport Source:InterPro
Biological Process late endosome to lysosome transport Source:UniProtKB1 Publication
Biological Process regulation of SNARE complex assembly Source:ComplexPortal1 Publication

Cellular Location

Cytoplasm
Lysosome membrane
Late endosome membrane
Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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