Mouse Anti-VSIR Recombinant Antibody (CBT4087) (V2LY-0625-LY830)

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Tested Data
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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBT4087
Application
FC
Immunogen
Purified recombinant fragment of human VISTA (AA: extra 33-194) expressed in HEK293 cells.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
V-set immunoregulatory receptor
Entrez Gene ID
Function
Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993).
May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity).
May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).
Biological Process
Biological Process negative regulation of alpha-beta T cell activation Source:GO_Central1 Publication
Biological Process negative regulation of CD4-positive, alpha-beta T cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of CD8-positive, alpha-beta T cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-10 production Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-17 production Source:UniProtKB1 Publication
Biological Process negative regulation of tumor necrosis factor production Source:UniProtKB1 Publication
Biological Process negative regulation of type II interferon production Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of collagen catabolic process Source:UniProtKB1 Publication
Biological Process positive regulation of endopeptidase activity Source:UniProtKB1 Publication
Biological Process positive regulation of gene expression Source:UniProtKB1 Publication
Biological Process positive regulation of regulatory T cell differentiation Source:UniProtKB1 Publication
Biological Process regulation of immune response Source:InterPro
Biological Process zymogen activation Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 33-194
Helical: 195-215
Cytoplasmic: 216-311
PTM
At the cell surface, may be cleaved by MMP14.
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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