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Mouse Anti-VSIR Recombinant Antibody (CBT4087) (V2LY-0625-LY830)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4087
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human VISTA (AA: extra 33-194) expressed in HEK293 cells.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
V-set immunoregulatory receptor
Entrez Gene ID
64115
Function
Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993).
May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity).
May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).
Biological Process
Biological Process negative regulation of alpha-beta T cell activation Source:GO_Central1 Publication
Biological Process negative regulation of CD4-positive, alpha-beta T cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of CD8-positive, alpha-beta T cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-10 production Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-17 production Source:UniProtKB1 Publication
Biological Process negative regulation of tumor necrosis factor production Source:UniProtKB1 Publication
Biological Process negative regulation of type II interferon production Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of collagen catabolic process Source:UniProtKB1 Publication
Biological Process positive regulation of endopeptidase activity Source:UniProtKB1 Publication
Biological Process positive regulation of gene expression Source:UniProtKB1 Publication
Biological Process positive regulation of regulatory T cell differentiation Source:UniProtKB1 Publication
Biological Process regulation of immune response Source:InterPro
Biological Process zymogen activation Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 33-194
Helical: 195-215
Cytoplasmic: 216-311
PTM
At the cell surface, may be cleaved by MMP14.
N-glycosylated.
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For research use only. Not intended for any clinical use.

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