VSIR

VSIR (V-Set Immunoregulatory Receptor) is a Protein Coding gene. Diseases associated with VSIR include Parasagittal Meningioma and Solar Retinopathy. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and NF-kappaB Signaling.
Full Name
V-set immunoregulatory receptor
Function
Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993).
May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity).
May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).
Biological Process
Biological Process negative regulation of alpha-beta T cell activation Source:GO_Central1 Publication
Biological Process negative regulation of CD4-positive, alpha-beta T cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of CD8-positive, alpha-beta T cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-10 production Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-17 production Source:UniProtKB1 Publication
Biological Process negative regulation of tumor necrosis factor production Source:UniProtKB1 Publication
Biological Process negative regulation of type II interferon production Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of collagen catabolic process Source:UniProtKB1 Publication
Biological Process positive regulation of endopeptidase activity Source:UniProtKB1 Publication
Biological Process positive regulation of gene expression Source:UniProtKB1 Publication
Biological Process positive regulation of regulatory T cell differentiation Source:UniProtKB1 Publication
Biological Process regulation of immune response Source:InterPro
Biological Process zymogen activation Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 33-194
Helical: 195-215
Cytoplasmic: 216-311
PTM
At the cell surface, may be cleaved by MMP14.
N-glycosylated.
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Anti-VSIR antibodies

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Mouse Anti-VSIR Recombinant Antibody (CBWJC-4580) (CBMAB-C5984WJ)

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Target: VSIR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4580
Application*: IH
Datasheet SDS

Mouse Anti-VSIR Recombinant Antibody (CBWJC-4579) (CBMAB-C5983WJ)

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Target: VSIR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4579
Application*: IH, WB
Datasheet SDS

Mouse Anti-VSIR Recombinant Antibody (MM0741-29N17) (CBMAB-G6682-LY)

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Target: VSIR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: MM0741-29N17
Application*: WB
Datasheet SDS

Mouse Anti-VSIR Recombinant Antibody (730804) (CBMAB-G1226-LY)

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Target: VSIR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 730804
Application*: F
Datasheet SDS

Rhesus Recombinant VSIR protein, ECD, His Tag (V2LY-0526-LY9803)

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Target: VSIR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-194
Tag: His Tag
Datasheet SDS

Rhesus Recombinant VSIR protein, ECD, hFc Tag (V2LY-0526-LY9802)

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Target: VSIR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-194
Tag: hFc Tag
Datasheet SDS

Rat Recombinant VSIR protein, ECD, hFc Tag (V2LY-0526-LY9638)

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Target: VSIR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-191
Tag: hFc Tag
Datasheet SDS

Mouse Recombinant VSIR protein, ECD, His Tag (V2LY-0526-LY9069)

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Target: VSIR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-191
Tag: His Tag
Datasheet SDS

Mouse Recombinant VSIR protein, ECD, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY9068)

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Target: VSIR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-191
Tag: His & AVI Tag
Datasheet SDS

Mouse Recombinant VSIR protein, ECD, hFc Tag (V2LY-0526-LY9067)

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Target: VSIR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-191
Tag: hFc Tag
Datasheet SDS

Human Recombinant VSIR protein, His Tag (V2LY-0526-LY7630)

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Target: VSIR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-194
Tag: His Tag
Datasheet SDS

Human Recombinant VSIR protein, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY7629)

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Target: VSIR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-194
Tag: His & AVI Tag
Datasheet SDS

Human Recombinant VSIR protein, ECD, hFc Tag (V2LY-0526-LY7628)

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Target: VSIR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-194
Tag: hFc Tag
Datasheet SDS

Cynomolgus Recombinant VISTA protein, His Tag (V2LY-0526-LY1670)

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Target: VSIR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-194
Tag: His Tag
Datasheet SDS

Cynomolgus Recombinant VISTA protein, hFc Tag (V2LY-0526-LY1669)

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Target: VSIR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-194
Tag: hFc Tag
Datasheet SDS

Mouse Anti-VSIR Recombinant Antibody (CBT4087) (V2LY-0625-LY830)

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Target: VSIR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4087
Application*: F
Datasheet SDS

Rabbit Anti-VSIR Recombinant Antibody (CBR035F) (CBMAB-BT097LY)

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Target: VSIR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR035F
Application*: WB, IP, IHC, ICC, IHC-IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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