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Rabbit Anti-VTCN1 Recombinant Antibody (CBYCV-129) (CBMAB-V0086-YC)

Provided herein is a Rabbit monoclonal antibody against Human VTCN1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all VTCN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBYCV-129
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
An 18 amino acid peptide near the center of human VTCN1
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Internal

Target

Full Name
V-set domain containing T cell activation inhibitor 1
Introduction
VTCN1 is a protein belonging to the B7 costimulatory protein family.Studies have shown that high levels of VTCN1 has been correlated with tumor progression.
Entrez Gene ID
Human79679
Mouse242122
UniProt ID
HumanQ7Z7D3
MouseQ7TSP5
Alternative Names
V-Set Domain Containing T Cell Activation Inhibitor 1; Immune Costimulatory Protein B7-H4; B7 Superfamily Member 1; B7 Family Member, H4; B7 Homolog 4; B7-H4; B7h.5; B7H4; V-Set Domain-Containing T-Cell Activation Inhibitor 1
Function
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of T cell activation Source:UniProtKB1 Publication
Biological Process negative regulation of T cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-2 production Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process regulation of cytokine production Source:GO_Central1 Publication
Biological Process response to protozoan Source:Ensembl
Biological Process T cell receptor signaling pathway Source:GO_Central1 Publication
Cellular Location
Cell membrane
Expressed at the cell surface. A soluble form has also been detected.
Topology
Extracellular: 25-259
Helical: 260-280
Cytoplasmic: 281-282
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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