VTCN1

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Full Name
V-set domain containing T cell activation inhibitor 1
Function
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of T cell activation Source:UniProtKB1 Publication
Biological Process negative regulation of T cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-2 production Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process regulation of cytokine production Source:GO_Central1 Publication
Biological Process response to protozoan Source:Ensembl
Biological Process T cell receptor signaling pathway Source:GO_Central1 Publication
Cellular Location
Cell membrane
Expressed at the cell surface. A soluble form has also been detected.
Topology
Extracellular: 25-259
Helical: 260-280
Cytoplasmic: 281-282
PTM
N-glycosylated.
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Anti-VTCN1 antibodies

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Rabbit Anti-VTCN1 Recombinant Antibody (CBR043F) (CBMAB-BT098LY)

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Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR043F
Application*: WB, IP, IHC, ICC, IHC-IF
Datasheet SDS

Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1831) (CBMAB-2180-YY)

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Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1831
Application*: F, IH
Datasheet SDS

Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1766) (CBMAB-2115-YY)

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Target: VTCN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1766
Application*: F, MC
Datasheet SDS

Rat Anti-VTCN1 Recombinant Antibody (CBYY-1731) (CBMAB-2080-YY)

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Target: VTCN1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-1731
Application*: F, WB
Datasheet SDS

Rabbit Anti-VTCN1 Recombinant Antibody (CBYY-1526) (CBMAB-1596-YY)

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Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYY-1526
Application*: WB, IP, P, IC
Datasheet SDS

Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1525) (CBMAB-1595-YY)

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Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1525
Application*: F
Datasheet SDS

Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1524) (CBMAB-1594-YY)

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Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1524
Application*: F
Datasheet SDS

Rat Anti-VTCN1 Recombinant Antibody (CBYY-1523) (CBMAB-1593-YY)

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Target: VTCN1
Host: Rat
Specificity: Mouse
Clone: CBYY-1523
Application*: F
Datasheet SDS

Rabbit Anti-VTCN1 Recombinant Antibody (D1M8I) (CBMAB-V0092-YC)

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Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1M8I
Application*: WB, P
Datasheet SDS

Mouse Anti-VTCN1 Recombinant Antibody (10B249) (CBMAB-V0091-YC)

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Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B249
Application*: F, IH
Datasheet SDS

Mouse Anti-VTCN1 Recombinant Antibody (MIH43) (CBMAB-V0090-YC)

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Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MIH43
Application*: F, C, P
Datasheet SDS

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-131) (CBMAB-V0089-YC)

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Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-131
Application*: E
Datasheet SDS

Mouse Anti-VTCN1 Recombinant Antibody (13j96) (CBMAB-V0088-YC)

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Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13j96
Application*: E, IC, IH, WB
Datasheet SDS

Rabbit Anti-VTCN1 Recombinant Antibody (CBYCV-130) (CBMAB-V0087-YC)

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Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCV-130
Application*: WB, IP, P, IC
Datasheet SDS

Rabbit Anti-VTCN1 Recombinant Antibody (CBYCV-129) (CBMAB-V0086-YC)

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Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYCV-129
Application*: E, WB
Datasheet SDS

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-104) (CBMAB-V0014-YC)

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Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-104
Application*: E, WB
Datasheet SDS

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-103) (CBMAB-V0013-YC)

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Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-103
Application*: IC, C, P, E, WB
Datasheet SDS

Rat Anti-VTCN1 Recombinant Antibody (AL-01) (CBMAB-V0012-YC)

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Target: VTCN1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: AL-01
Application*: F
Datasheet SDS

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-102) (CBMAB-V0011-YC)

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Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-102
Application*: WB
Datasheet SDS

Rat Anti-VTCN1 Recombinant Antibody (188) (CBMAB-V0009-YC)

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Target: VTCN1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 188
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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