VTCN1
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Full Name
V-set domain containing T cell activation inhibitor 1
Function
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of T cell activation Source:UniProtKB1 Publication
Biological Process negative regulation of T cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-2 production Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process regulation of cytokine production Source:GO_Central1 Publication
Biological Process response to protozoan Source:Ensembl
Biological Process T cell receptor signaling pathway Source:GO_Central1 Publication
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of T cell activation Source:UniProtKB1 Publication
Biological Process negative regulation of T cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-2 production Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process regulation of cytokine production Source:GO_Central1 Publication
Biological Process response to protozoan Source:Ensembl
Biological Process T cell receptor signaling pathway Source:GO_Central1 Publication
Cellular Location
Cell membrane
Expressed at the cell surface. A soluble form has also been detected.
Expressed at the cell surface. A soluble form has also been detected.
Topology
Extracellular: 25-259
Helical: 260-280
Cytoplasmic: 281-282
Helical: 260-280
Cytoplasmic: 281-282
PTM
N-glycosylated.
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Anti-VTCN1 antibodies
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CompareTarget: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR043F
Application*: WB, IP, IHC, ICC, IHC-IF
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1831
Application*: F, IH
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1766
Application*: F, MC
Target: VTCN1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-1731
Application*: F, WB
Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYY-1526
Application*: WB, IP, P, IC
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1525
Application*: F
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1524
Application*: F
Target: VTCN1
Host: Rat
Specificity: Mouse
Clone: CBYY-1523
Application*: F
Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1M8I
Application*: WB, P
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B249
Application*: F, IH
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MIH43
Application*: F, C, P
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-131
Application*: E
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13j96
Application*: E, IC, IH, WB
Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCV-130
Application*: WB, IP, P, IC
Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYCV-129
Application*: E, WB
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-104
Application*: E, WB
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-103
Application*: IC, C, P, E, WB
Target: VTCN1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: AL-01
Application*: F
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-102
Application*: WB
Target: VTCN1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 188
Application*: F
Target: VTCN1
Sensitivity: 1.35 ng/mL
Detection Range: 3-900 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: VTCN1
Sensitivity: 0.021 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-256
Tag: His Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-256
Tag: His Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-256
Tag: His Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-256
Tag: hFc Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-258
Tag: Fc Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-258
Tag: His Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-258
Tag: hFc Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-258
Tag: His Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-258
Tag: His Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-258
Tag: His & AVI Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-258
Tag: His & AVI Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-258
Tag: hFc Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-258
Tag: hFc Tag
Target: VTCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-258
Tag: His Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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