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VTCN1

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Full Name
V-set domain containing T cell activation inhibitor 1
Function
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of T cell activation Source:UniProtKB1 Publication
Biological Process negative regulation of T cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-2 production Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process regulation of cytokine production Source:GO_Central1 Publication
Biological Process response to protozoan Source:Ensembl
Biological Process T cell receptor signaling pathway Source:GO_Central1 Publication
Cellular Location
Cell membrane
Expressed at the cell surface. A soluble form has also been detected.
Topology
Extracellular: 25-259
Helical: 260-280
Cytoplasmic: 281-282
PTM
N-glycosylated.

Anti-VTCN1 antibodies

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Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1831) (CBMAB-2180-YY)

Datasheet SDS
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1831
Application*: F, IH

Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1766) (CBMAB-2115-YY)

Datasheet SDS
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1766
Application*: F, MC

Rat Anti-VTCN1 Recombinant Antibody (CBYY-1731) (CBMAB-2080-YY)

Datasheet SDS
Target: VTCN1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-1731
Application*: F, WB

Rabbit Anti-VTCN1 Recombinant Antibody (CBYY-1526) (CBMAB-1596-YY)

Datasheet SDS
Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYY-1526
Application*: WB, IP, P, IC

Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1525) (CBMAB-1595-YY)

Datasheet SDS
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1525
Application*: F

Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1524) (CBMAB-1594-YY)

Datasheet SDS
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1524
Application*: F

Rat Anti-VTCN1 Recombinant Antibody (CBYY-1523) (CBMAB-1593-YY)

Datasheet SDS
Target: VTCN1
Host: Rat
Specificity: Mouse
Clone: CBYY-1523
Application*: F

Rabbit Anti-VTCN1 Recombinant Antibody (D1M8I) (CBMAB-V0092-YC)

Datasheet SDS
Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1M8I
Application*: WB, P

Mouse Anti-VTCN1 Recombinant Antibody (10B249) (CBMAB-V0091-YC)

Datasheet SDS
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B249
Application*: F, IH

Mouse Anti-VTCN1 Recombinant Antibody (MIH43) (CBMAB-V0090-YC)

Datasheet SDS
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MIH43
Application*: F, C, P

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-131) (CBMAB-V0089-YC)

Datasheet SDS
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-131
Application*: E

Mouse Anti-VTCN1 Recombinant Antibody (13j96) (CBMAB-V0088-YC)

Datasheet SDS
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13j96
Application*: E, IC, IH, WB

Rabbit Anti-VTCN1 Recombinant Antibody (CBYCV-130) (CBMAB-V0087-YC)

Datasheet SDS
Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCV-130
Application*: WB, IP, P, IC

Rabbit Anti-VTCN1 Recombinant Antibody (CBYCV-129) (CBMAB-V0086-YC)

Datasheet SDS
Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYCV-129
Application*: E, WB

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-104) (CBMAB-V0014-YC)

Datasheet SDS
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-104
Application*: E, WB

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-103) (CBMAB-V0013-YC)

Datasheet SDS
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-103
Application*: IC, C, P, E, WB

Rat Anti-VTCN1 Recombinant Antibody (AL-01) (CBMAB-V0012-YC)

Datasheet SDS
Target: VTCN1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: AL-01
Application*: F

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-102) (CBMAB-V0011-YC)

Datasheet SDS
Target: VTCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-102
Application*: WB

Rat Anti-VTCN1 Recombinant Antibody (188) (CBMAB-V0009-YC)

Datasheet SDS
Target: VTCN1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 188
Application*: F

Rabbit Anti-VTCN1 Recombinant Antibody (CBR043F) (CBMAB-BT098LY)

Datasheet SDS
Target: VTCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR043F
Application*: WB, IP, IHC, ICC, IHC-IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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