Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1524) (CBMAB-1594-YY)

Name: Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1524)
SKU: CBMAB-1594-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYY-1524

Application

Immunogen

Recognizes human B7H4

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

V-set domain containing T cell activation inhibitor 1

Introduction

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforMouse have been found for this gene.

Entrez Gene ID

79679

UniProt ID

Q7Z7D3

Alternative Names

V-Set Domain Containing T Cell Activation Inhibitor 1; Immune Costimulatory Protein B7-H4; B7 Superfamily Member 1; B7 Family Member, H4; B7 Homolog 4; B7-H4; B7h.5; B7H4; V-Set Domain-Containing T-Cell Activation Inhibitor 1;

Function

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Biological Process

Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of T cell activation Source:UniProtKB1 Publication
Biological Process negative regulation of T cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-2 production Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process regulation of cytokine production Source:GO_Central1 Publication
Biological Process response to protozoan Source:Ensembl
Biological Process T cell receptor signaling pathway Source:GO_Central1 Publication

Cellular Location

Cell membrane
Expressed at the cell surface. A soluble form has also been detected.

Topology

Extracellular: 25-259
Helical: 260-280
Cytoplasmic: 281-282

PTM

N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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