Mouse Anti-WASF1 Recombinant Antibody (CBYY-1594) (CBMAB-1665-YY)

Name: Mouse Anti-WASF1 Recombinant Antibody (CBYY-1594)
SKU: CBMAB-1665-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYY-1594

Application

Specificity

Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

WAS protein family, member 1

Introduction

The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

83767

UniProt ID

Q8R5H6

Alternative Names

WAS Protein Family Member 1; Verprolin Homology Domain-Containing Protein 1; WASP Family Protein Member 1; Protein WAVE-1; SCAR1; WAVE1;

Function

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568).
The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity).
As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Also involved in the regulation of mitochondrial dynamics (PubMed:29961568).

Biological Process

Biological Process actin cytoskeleton organization Source:UniProtKB1 Publication
Biological Process actin filament polymerization Source:ProtInc1 Publication
Biological Process cellular response to brain-derived neurotrophic factor stimulus Source:UniProtKB
Biological Process dendrite extension Source:Ensembl
Biological Process dendritic transport of mitochondrion Source:Ensembl
Biological Process lamellipodium morphogenesis Source:UniProtKB1 Publication
Biological Process mitochondrion morphogenesis Source:UniProtKB1 Publication
Biological Process modification of postsynaptic actin cytoskeleton Source:Ensembl
Biological Process positive regulation of Arp2/3 complex-mediated actin nucleation Source:UniProtKB1 Publication
Biological Process positive regulation of neurotrophin TRK receptor signaling pathway Source:Ensembl
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process Rac protein signal transduction Source:UniProtKB1 Publication
Biological Process receptor-mediated endocytosis Source:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton
Synapse
Cell junction, focal adhesion
Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097).
Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503).
In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity).

Involvement in disease

Neurodevelopmental disorder with absent language and variable seizures (NEDALVS):
A disorder characterized by neurodevelopmental abnormalities, including moderate to profound intellectual disability, with autistic features, seizures, severe impairments in speech, and gross motor delay.

PTM

Phosphorylated on tyrosine residues by ABL1 and dephosphorylated by PTPN12.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-WASF1 Recombinant Antibody (CBYY-1644) (CAT#: CBMAB-1715-YY)

Rabbit Anti-WASF1 Recombinant Antibody (CBYY-1634) (CAT#: CBMAB-1705-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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