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Mouse Anti-WASF1 Recombinant Antibody (CBYY-1644) (CBMAB-1715-YY)

This product is mouse antibody that recognizes WASF1. The antibody CBYY-1644 can be used for immunoassay techniques such as: IS, WB, IHC
See all WASF1 antibodies

Summary

Host Animal
Mouse
Specificity
Mammalian
Clone
CBYY-1644
Antibody Isotype
IgG1
Application
IS, WB, IHC

Basic Information

Specificity
Mammalian
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WAS protein family, member 1
Introduction
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
Entrez Gene ID
8936
UniProt ID
Q92558
Alternative Names
WAS Protein Family Member 1; Verprolin Homology Domain-Containing Protein 1; WASP Family Protein Member 1; Protein WAVE-1; SCAR1; WAVE1;
Function
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568).
The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity).
As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Also involved in the regulation of mitochondrial dynamics (PubMed:29961568).
Biological Process
Biological Process actin cytoskeleton organization Source:UniProtKB1 Publication
Biological Process actin filament polymerization Source:ProtInc1 Publication
Biological Process cellular response to brain-derived neurotrophic factor stimulus Source:UniProtKB
Biological Process dendrite extension Source:Ensembl
Biological Process dendritic transport of mitochondrion Source:Ensembl
Biological Process lamellipodium morphogenesis Source:UniProtKB1 Publication
Biological Process mitochondrion morphogenesis Source:UniProtKB1 Publication
Biological Process modification of postsynaptic actin cytoskeleton Source:Ensembl
Biological Process positive regulation of Arp2/3 complex-mediated actin nucleation Source:UniProtKB1 Publication
Biological Process positive regulation of neurotrophin TRK receptor signaling pathway Source:Ensembl
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process Rac protein signal transduction Source:UniProtKB1 Publication
Biological Process receptor-mediated endocytosis Source:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton
Synapse
Cell junction, focal adhesion
Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097).
Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503).
In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity).
Involvement in disease
Neurodevelopmental disorder with absent language and variable seizures (NEDALVS):
A disorder characterized by neurodevelopmental abnormalities, including moderate to profound intellectual disability, with autistic features, seizures, severe impairments in speech, and gross motor delay.
PTM
Phosphorylated on tyrosine residues by ABL1 and dephosphorylated by PTPN12.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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