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Mouse Anti-WDR4 Recombinant Antibody (CBWJW-002) (CBMAB-W0161-WJ)

This product is a mouse antibody that recognizes WDR4. The antibody CBWJW-002 can be used for immunoassay techniques such as: WB, IHC-P.
See all WDR4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJW-002
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WD repeat domain 4
Introduction
WDR4 is a protein-coding gene encodes a member of the WD repeat protein family. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Diseases associated with WDR4 include Isolated Growth Hormone Deficiency, Type Ia and Nonsyndromic Deafness. The related pathways are Gene Expression and tRNA processing.
Entrez Gene ID
10785
UniProt ID
P57081
Alternative Names
TRM82; TRMT82
Function
Non-catalytic component of a methyltransferase complex required for the formation of N7-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083).
In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit (PubMed:12403464).
Required for the formation of N7-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084).
Also required for the formation of N7-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084).
Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083).
Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069).
Biological Process
Biological Process cellular response to DNA damage stimulus Source:UniProtKB-KW
Biological Process tRNA (guanine-N7)-methylation Source:GOC
Biological Process tRNA modification Source:UniProtKB1 Publication
Cellular Location
Nucleus
Chromosome
Localizes at the site of nascent DNA synthesis.
Involvement in disease
Galloway-Mowat syndrome 6 (GAMOS6):
A form of Galloway-Mowat syndrome, a severe renal-neurological disease characterized by early-onset nephrotic syndrome associated with microcephaly, central nervous system abnormalities, developmental delays, and a propensity for seizures. Brain anomalies include gyration defects ranging from lissencephaly to pachygyria and polymicrogyria, and cerebellar hypoplasia. Most patients show facial dysmorphism characterized by a small, narrow forehead, large/floppy ears, deep-set eyes, hypertelorism and micrognathia. Additional variable features are visual impairment and arachnodactyly. Most patients die in early childhood. GAMOS6 is an autosomal recessive form with onset in infancy or early childhood. Affected individuals manifest microcephaly, global developmental delay, variable degrees of intellectual disability, and growth deficiency. Renal impairment may be age-dependent or may not be present.
Microcephaly, growth deficiency, seizures, and brain malformations (MIGSB):
An autosomal recessive disorder characterized by intrauterine growth retardation, postnatal growth deficiency, microcephaly, facial dysmorphism, early-onset seizures, brain malformations such as partial agenesis of the corpus callosum and simplified gyration, and poor or absent psychomotor development.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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