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Rabbit Anti-WDR5 Recombinant Antibody (D9E1I) (CBMAB-CP3010-LY)

The product is antibody recognizes WDR5. The antibody D9E1I immunoassay techniques such as: WB,CIP,CIP-seq.
See all WDR5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D9E1I
Antibody Isotype
IgG
Application
WB, CIP, CIP-seq

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to full-length human WDR5 protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
WD Repeat Domain 5
Introduction
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human11091
Mouse140858
Rat362093
Monkey722123
UniProt ID
HumanP61964
MouseP61965
RatQ498M4
MonkeyF7AMK0
Alternative Names
WD Repeat Domain 5; Cilia And Flagella Associated Protein 89; BMP2-Induced 3-Kb Gene Protein; SWD3; Set1c WD40 Repeat Protein; Homolog (S. Cerevisiae); SWD3; Set1c WD40 Repeat Protein; Homolog; WD Repeat-Containing Protein 5;
Function
Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960).
May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960).
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606).
As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852).
May regulate osteoblasts differentiation (By similarity).
In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).
Biological Process
Biological Process gluconeogenesis Source:Ensembl
Biological Process histone H3 acetylation Source:BHF-UCL1 Publication
Biological Process histone H3-K14 acetylation Source:ComplexPortal1 Publication
Biological Process histone H3-K4 methylation Source:GO_Central1 Publication
Biological Process histone H4-K16 acetylation Source:ComplexPortal1 Publication
Biological Process histone H4-K5 acetylation Source:ComplexPortal1 Publication
Biological Process histone H4-K8 acetylation Source:ComplexPortal1 Publication
Biological Process negative regulation of histone H3-K4 methylation Source:CACAO1 Publication
Biological Process neuron projection development Source:Ensembl
Biological Process positive regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process positive regulation of gluconeogenesis Source:Ensembl
Biological Process positive regulation of histone H3-K4 methylation Source:CACAO1 Publication
Biological Process regulation of cell cycle Source:ComplexPortal1 Publication
Biological Process regulation of cell division Source:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process regulation of dosage compensation by inactivation of X chromosome Source:ComplexPortal
Biological Process regulation of embryonic development Source:ComplexPortal
Biological Process regulation of histone deacetylation Source:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process regulation of tubulin deacetylation Source:ComplexPortal1 Publication
Biological Process skeletal system development Source:Ensembl
Biological Process transcription initiation-coupled chromatin remodeling Source:UniProtKB1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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