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Mouse Anti-WNK2 Recombinant Antibody (2A2) (CBMAB-W0062-WJ)

This product is a mouse antibody that recognizes WNK2. The antibody 2A2 can be used for immunoassay techniques such as: ELISA, WB.
See all WNK2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A2
Antibody Isotype
IgG1, к
Application
ELISA, WB

Basic Information

Immunogen
WNK2 (NP_006639, aa2118-2217) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: KGTFTDDLHK LVDEWTSKTV GAAQLKPTLN QLKQTQKLQD MEAQAGWAAP GEARAMTAPR AGVGMPRLPP APGPLSTTVI PGAAPTLSVP TPDPESEKPD
Specificity
Human
Antibody Isotype
IgG1, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WNK lysine deficient protein kinase 2
Introduction
WNK2 is a protein-coding gene encodes the protein which is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. Diseases associated with WNK2 include Gastric Cardia Carcinoma. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WNK1.
Entrez Gene ID
65268
UniProt ID
Q9Y3S1
Alternative Names
PRKWNK2; NY-CO-43; SDCCAG43; P/OKcl.13
Function
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
Biological Process
Biological Process intracellular signal transduction Source:UniProtKB
Biological Process ion homeostasis Source:UniProtKB1 Publication
Biological Process negative regulation of cell population proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of ERK1 and ERK2 cascade Source:UniProtKB1 Publication
Biological Process negative regulation of sodium ion transport Source:GO_Central1 Publication
Biological Process positive regulation of canonical Wnt signaling pathway Source:FlyBase1 Publication
Biological Process positive regulation of potassium ion import across plasma membrane Source:GO_Central1 Publication
Biological Process positive regulation of sodium ion transmembrane transporter activity Source:UniProtKB1 Publication
Biological Process protein autophosphorylation Source:UniProtKB1 Publication
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Cell membrane
PTM
Autophosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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