Rat Anti-WNT11 Recombinant Antibody (CBWJW-190) (CBMAB-W0077-WJ)

wingless-type MMTV integration site family, member 11

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein. Diseases associated with WNT11 include Mass Syndrome. An important paralog of this gene is WNT5B.

WNT11; wingless-type MMTV integration site family, member 11

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Biological Process adrenal gland development Source:UniProtKB1 Publication
Biological Process artery morphogenesis Source:Ensembl
Biological Process atrial septum development Source:Ensembl
Biological Process bicellular tight junction assembly Source:Ensembl
Biological Process bone mineralization Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to mechanical stimulus Source:Ensembl
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process cloacal septation Source:UniProtKB1 Publication
Biological Process convergent extension involved in axis elongation Source:Ensembl
Biological Process embryonic skeletal system development Source:UniProtKB1 Publication
Biological Process epithelial cell apoptotic process Source:Ensembl
Biological Process epithelial to mesenchymal transition Source:Ensembl
Biological Process lung-associated mesenchyme development Source:UniProtKB1 Publication
Biological Process maintenance of epithelial cell apical/basal polarity Source:Ensembl
Biological Process mesenchymal cell proliferation Source:Ensembl
Biological Process mesonephric duct development Source:UniProtKB1 Publication
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of canonical Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of cartilage development Source:UniProtKB1 Publication
Biological Process negative regulation of cell death Source:UniProtKB1 Publication
Biological Process negative regulation of cell growth Source:UniProtKB1 Publication
Biological Process negative regulation of cell migration Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB2 Publications
Biological Process negative regulation of fibroblast growth factor production Source:Ensembl
Biological Process negative regulation of mesenchymal cell proliferation Source:Ensembl
Biological Process negative regulation of stem cell proliferation Source:Ensembl
Biological Process neuroendocrine cell differentiation Source:UniProtKB1 Publication
Biological Process neuron differentiation Source:UniProtKB
Biological Process notochord morphogenesis Source:Ensembl
Biological Process osteoblast differentiation Source:Ensembl
Biological Process outflow tract morphogenesis Source:Ensembl
Biological Process paraxial mesoderm formation Source:Ensembl
Biological Process planar cell polarity pathway involved in axis elongation Source:Ensembl
Biological Process planar cell polarity pathway involved in gastrula mediolateral intercalation Source:Ensembl
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of epithelial cell apoptotic process Source:Ensembl
Biological Process positive regulation of gene expression Source:UniProtKB1 Publication
Biological Process positive regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Source:Ensembl
Biological Process positive regulation of protein kinase C signaling Source:UniProtKB1 Publication
Biological Process positive regulation of stress fiber assembly Source:UniProtKB1 Publication
Biological Process positive regulation of transforming growth factor beta2 production Source:Ensembl
Biological Process primary heart field specification Source:Ensembl
Biological Process protein localization to cell surface Source:UniProtKB1 Publication
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process response to nutrient levels Source:Ensembl
Biological Process secondary heart field specification Source:Ensembl
Biological Process secondary palate development Source:BHF-UCL1 Publication
Biological Process somite development Source:Ensembl
Biological Process stem cell proliferation Source:Ensembl
Biological Process ureteric bud morphogenesis Source:UniProtKB1 Publication
Biological Process ventricular septum morphogenesis Source:Ensembl
Biological Process Wnt signaling pathway, calcium modulating pathway Source:ParkinsonsUK-UCL1 Publication
Biological Process Wnt signaling pathway, planar cell polarity pathway Source:ParkinsonsUK-UCL1 Publication

Secreted, extracellular space, extracellular matrix

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.