WNT11

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome.

wingless-type MMTV integration site family, member 11

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Biological Process adrenal gland development Source:UniProtKB1 Publication
Biological Process artery morphogenesis Source:Ensembl
Biological Process atrial septum development Source:Ensembl
Biological Process bicellular tight junction assembly Source:Ensembl
Biological Process bone mineralization Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to mechanical stimulus Source:Ensembl
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process cloacal septation Source:UniProtKB1 Publication
Biological Process convergent extension involved in axis elongation Source:Ensembl
Biological Process embryonic skeletal system development Source:UniProtKB1 Publication
Biological Process epithelial cell apoptotic process Source:Ensembl
Biological Process epithelial to mesenchymal transition Source:Ensembl
Biological Process lung-associated mesenchyme development Source:UniProtKB1 Publication
Biological Process maintenance of epithelial cell apical/basal polarity Source:Ensembl
Biological Process mesenchymal cell proliferation Source:Ensembl
Biological Process mesonephric duct development Source:UniProtKB1 Publication
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of canonical Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of cartilage development Source:UniProtKB1 Publication
Biological Process negative regulation of cell death Source:UniProtKB1 Publication
Biological Process negative regulation of cell growth Source:UniProtKB1 Publication
Biological Process negative regulation of cell migration Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB2 Publications
Biological Process negative regulation of fibroblast growth factor production Source:Ensembl
Biological Process negative regulation of mesenchymal cell proliferation Source:Ensembl
Biological Process negative regulation of stem cell proliferation Source:Ensembl
Biological Process neuroendocrine cell differentiation Source:UniProtKB1 Publication
Biological Process neuron differentiation Source:UniProtKB
Biological Process notochord morphogenesis Source:Ensembl
Biological Process osteoblast differentiation Source:Ensembl
Biological Process outflow tract morphogenesis Source:Ensembl
Biological Process paraxial mesoderm formation Source:Ensembl
Biological Process planar cell polarity pathway involved in axis elongation Source:Ensembl
Biological Process planar cell polarity pathway involved in gastrula mediolateral intercalation Source:Ensembl
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of epithelial cell apoptotic process Source:Ensembl
Biological Process positive regulation of gene expression Source:UniProtKB1 Publication
Biological Process positive regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Source:Ensembl
Biological Process positive regulation of protein kinase C signaling Source:UniProtKB1 Publication
Biological Process positive regulation of stress fiber assembly Source:UniProtKB1 Publication
Biological Process positive regulation of transforming growth factor beta2 production Source:Ensembl
Biological Process primary heart field specification Source:Ensembl
Biological Process protein localization to cell surface Source:UniProtKB1 Publication
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process response to nutrient levels Source:Ensembl
Biological Process secondary heart field specification Source:Ensembl
Biological Process secondary palate development Source:BHF-UCL1 Publication
Biological Process somite development Source:Ensembl
Biological Process stem cell proliferation Source:Ensembl
Biological Process ureteric bud morphogenesis Source:UniProtKB1 Publication
Biological Process ventricular septum morphogenesis Source:Ensembl
Biological Process Wnt signaling pathway, calcium modulating pathway Source:ParkinsonsUK-UCL1 Publication
Biological Process Wnt signaling pathway, planar cell polarity pathway Source:ParkinsonsUK-UCL1 Publication

Secreted, extracellular space, extracellular matrix

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.