Rabbit Anti-WNT6 Recombinant Antibody (BA0370) (CBMAB-0989CQ)

Name: Rabbit Anti-WNT6 Recombinant Antibody (BA0370)
SKU: CBMAB-0989CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

BA0370

Application

Immunogen

Synthetic peptide from residues in Human Wnt6

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Wnt family member 6

Introduction

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.

Entrez Gene ID

Human	7475
Mouse	22420
Rat	316526

UniProt ID

Human	Q9Y6F9
Mouse	P22727
Rat	D4A3W9

Alternative Names

Wnt family member 6

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.

Biological Process

Biological Process axis specification Source:Ensembl
Biological Process branching involved in ureteric bud morphogenesis Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process cornea development in camera-type eye Source:BHF-UCLBy Similarity
Biological Process epithelial-mesenchymal cell signaling Source:Ensembl
Biological Process nephron tubule formation Source:Ensembl
Biological Process neuron differentiation Source:UniProtKB
Biological Process odontogenesis of dentin-containing tooth Source:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcription Source:Ensembl
Biological Process positive regulation of gene expression Source:BHF-UCL1 Publication
Biological Process positive regulation of tooth mineralization Source:BHF-UCL1 Publication

Cellular Location

Secreted, extracellular space, extracellular matrix

PTM

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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