WNT6

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.

Full Name

Wnt family member 6

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.

Biological Process

Biological Process axis specification Source:Ensembl
Biological Process branching involved in ureteric bud morphogenesis Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process cornea development in camera-type eye Source:BHF-UCLBy Similarity
Biological Process epithelial-mesenchymal cell signaling Source:Ensembl
Biological Process nephron tubule formation Source:Ensembl
Biological Process neuron differentiation Source:UniProtKB
Biological Process odontogenesis of dentin-containing tooth Source:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcription Source:Ensembl
Biological Process positive regulation of gene expression Source:BHF-UCL1 Publication
Biological Process positive regulation of tooth mineralization Source:BHF-UCL1 Publication

Cellular Location

Secreted, extracellular space, extracellular matrix

PTM

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.