Mouse Anti-WRNIP1 Recombinant Antibody (CBWJW-136) (CBMAB-W0283-WJ)

Name: Mouse Anti-WRNIP1 Recombinant Antibody (CBWJW-136)
SKU: CBMAB-W0283-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBWJW-136

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Werner helicase interacting protein 1

Introduction

WRNIP1 is a protein-coding gene encodes the protein interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. Diseases associated with WRNIP1 include Brain Compression and Posterior Myocardial Infarction. Gene Ontology (GO) annotations related to this gene include identical protein binding and four-way junction helicase activity.

Entrez Gene ID

56897

UniProt ID

Q96S55

Alternative Names

WHIP; bA420G6.2

Function

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS.

Biological Process

Biological Process DNA synthesis involved in DNA repair Source:UniProtKB1 Publication
Biological Process DNA-templated DNA replication Source:GO_Central1 Publication
Biological Process innate immune response Source:UniProtKB-KW
Biological Process regulation of DNA repair Source:GO_Central1 Publication
Biological Process regulation of DNA-templated DNA replication initiation Source:UniProtKB1 Publication

Cellular Location

Nucleus
Cytoplasm
Colocalizes with WRN in granular structures in the nucleus.

PTM

Sumoylated with SUMO1 and SUMO2/3.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-WRNIP1 Recombinant Antibody (CBWJW-131) (CAT#: CBMAB-W0280-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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