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Mouse Anti-WRNIP1 Recombinant Antibody (CBWJW-166) (CBMAB-W0310-WJ)

This product is a mouse antibody that recognizes WRNIP1. The antibody CBWJW-166 can be used for immunoassay techniques such as: WB, IP, IF, IHC-P, ELISA.
See all WRNIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBWJW-166
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Werner helicase interacting protein 1
Introduction
WRNIP1 is a protein-coding gene encodes the protein interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. Diseases associated with WRNIP1 include Brain Compression and Posterior Myocardial Infarction. Gene Ontology (GO) annotations related to this gene include identical protein binding and four-way junction helicase activity.
Entrez Gene ID
Human56897
Mouse78903
Rat282835
UniProt ID
HumanQ96S55
MouseQ91XU0
RatQ8CG07
Alternative Names
WHIP; bA420G6.2
Function
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS.
Biological Process
Biological Process DNA synthesis involved in DNA repair Source:UniProtKB1 Publication
Biological Process DNA-templated DNA replication Source:GO_Central1 Publication
Biological Process innate immune response Source:UniProtKB-KW
Biological Process regulation of DNA repair Source:GO_Central1 Publication
Biological Process regulation of DNA-templated DNA replication initiation Source:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm
Colocalizes with WRN in granular structures in the nucleus.
PTM
Sumoylated with SUMO1 and SUMO2/3.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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