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Mouse Anti-XDH Recombinant Antibody (A-3) (CBMAB-X0118-YC)

Provided herein is a Mouse monoclonal antibody against Human XDH. The antibody, clone A-3, can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all XDH antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
A-3
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
xanthine dehydrogenase
Introduction
XDH is a key enzyme in purine degradation. XDH catalyzes the oxidation of hypoxanthine to xanthine and catalyzes the oxidation of xanthine to uric acid. XDH contributes to the generation of reactive oxygen species. XDH has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Defects in XDH cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
Entrez Gene ID
Human7498
Mouse22436
Rat497811
UniProt ID
HumanP47989
MouseQ00519
RatP22985
Alternative Names
XO; XOR; XAN1
Function
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).
Biological Process
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process Source:UniProtKB1 Publication
Biological Process adenosine catabolic process Source:Ensembl
Biological Process allantoin metabolic process Source:MGI1 Publication
Biological Process AMP catabolic process Source:MGI1 Publication
Biological Process dAMP catabolic process Source:Ensembl
Biological Process deoxyadenosine catabolic process Source:Ensembl
Biological Process deoxyguanosine catabolic process Source:Ensembl
Biological Process deoxyinosine catabolic process Source:MGI1 Publication
Biological Process dGMP catabolic process Source:Ensembl
Biological Process GMP catabolic process Source:Ensembl
Biological Process guanine catabolic process Source:Ensembl
Biological Process hypoxanthine catabolic process Source:MGI1 Publication
Biological Process IMP catabolic process Source:MGI1 Publication
Biological Process inosine catabolic process Source:MGI1 Publication
Biological Process iron-sulfur cluster assembly Source:Ensembl
Biological Process lactation Source:Ensembl
Biological Process negative regulation of endothelial cell differentiation Source:UniProtKB1 Publication
Biological Process negative regulation of endothelial cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of gene expression Source:UniProtKB1 Publication
Biological Process negative regulation of protein kinase B signaling Source:UniProtKB1 Publication
Biological Process negative regulation of protein phosphorylation Source:UniProtKB1 Publication
Biological Process negative regulation of vascular endothelial growth factor signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of vasculogenesis Source:UniProtKB1 Publication
Biological Process positive regulation of p38MAPK cascade Source:UniProtKB1 Publication
Biological Process positive regulation of reactive oxygen species metabolic process Source:UniProtKB1 Publication
Biological Process xanthine catabolic process Source:UniProtKB2 Publications
Cellular Location
Cytoplasm
Peroxisome
Secreted
Involvement in disease
Xanthinuria 1 (XAN1):
A disorder characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XAN1 is due to isolated xanthine dehydrogenase deficiency. Patients can metabolize allopurinol.
PTM
A disorder characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XAN1 is due to isolated xanthine dehydrogenase deficiency. Patients can metabolize allopurinol.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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