Mouse Anti-XPA Recombinant Antibody (2E4) (CBMAB-A9967-LY)

Name: Mouse Anti-XPA Recombinant Antibody (2E4)
SKU: CBMAB-A9967-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2E4

Application

WB, ELISA

Immunogen

XPA (NP_000371.1, 1 a.a. ~ 273 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

XPA, DNA Damage Recognition And Repair Factor

Introduction

This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

Entrez Gene ID

7507

UniProt ID

P23025

Alternative Names

XP1; XPAC

Function

Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.

Biological Process

Biological Process base-excision repair Source:GO_Central1 Publication
Biological Process DNA repair Source:CAFA1 Publication
Biological Process nucleotide-excision repair involved in interstrand cross-link repair Source:GO_Central1 Publication
Biological Process nucleotide-excision repair, DNA damage recognition Source:GO_Central1 Publication
Biological Process nucleotide-excision repair, DNA incision Source:CACAO1 Publication
Biological Process protein localization to nucleus Source:CAFA1 Publication
Biological Process UV protection Source:CAFA1 Publication
Biological Process UV-damage excision repair Source:GO_Central1 Publication

Cellular Location

Nucleus

Involvement in disease

Xeroderma pigmentosum complementation group A (XP-A):
An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. XP-A patients show the most severe skin symptoms and progressive neurological disorders.

PTM

ATR-dependent phosphorylation of XPA at Ser-196 is important for cell survival in response to UV damage.
Ubiquitinated by HERC2 leading to degradation by the proteasome.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

XPA Matched Antibody Pair (1309) (CAT#: APMAB-1309LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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