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Rabbit Anti-YWHAB Recombinant Antibody (9i142) (CBMAB-1259-LY)

This product is antibody recognizes YWHAB. The antibody 9i142 immunoassay techniques such as: WB, ELISA, IF.
See all YWHAB antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
9i142
Antibody Isotype
IgG
Application
FC, ICC, IHC, IP, WB

Basic Information

Immunogen
C-Terminal of Human 14-3-3 beta
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.15M sodium chloride, 0.05% BSA, 40% glycerol
Preservative
0.01% sodium azide,
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
YWHAB
Introduction
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Entrez Gene ID
Human7529
Mouse54401
Rat56011
UniProt ID
HumanP31946
MouseQ9CQV8
RatP35213
Alternative Names
HEL4; YWHAD; KCIP-1; HEL-S-3; HEL-S-93; 14-3-3-zeta
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
Biological Process
Biological Process cytoplasmic sequestering of protein Source:BHF-UCL1 Publication
Biological Process negative regulation of G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of protein dephosphorylation Source:BHF-UCL1 Publication
Biological Process positive regulation of catalytic activity Source:BHF-UCL1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process signal transduction Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Vacuole membrane
(Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG.
PTM
The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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