Mouse Anti-YWHAB Recombinant Antibody (CBT4563) (V2LY-0625-LY515)

Name: Mouse Anti-YWHAB Recombinant Antibody (CBT4563)
SKU: V2LY-0625-LY515
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-YWHAB Recombinant Antibody (CBT4563) (V2LY-0625-LY515) in WB

Mouse Anti-YWHAB Recombinant Antibody (CBT4563) (V2LY-0625-LY515) in IF

Mouse Anti-YWHAB Recombinant Antibody (CBT4563) (V2LY-0625-LY515) in FC

Mouse Anti-YWHAB Recombinant Antibody (CBT4563) (V2LY-0625-LY515) in IHC

Mouse Anti-YWHAB Recombinant Antibody (CBT4563) (V2LY-0625-LY515) in ELISA

Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4563

Application

WB, IHC, ICC, FC

Immunogen

Purified recombinant fragment of human YWHAB (AA: 1-246) expressed in E. Coli.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
ICC	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

YWHAB

Entrez Gene ID

7529

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.

Biological Process

Biological Process cytoplasmic sequestering of protein Source:BHF-UCL1 Publication
Biological Process negative regulation of G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of protein dephosphorylation Source:BHF-UCL1 Publication
Biological Process positive regulation of catalytic activity Source:BHF-UCL1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process signal transduction Source:GO_Central1 Publication

Cellular Location

Cytoplasm
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Vacuole membrane
(Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG.

PTM

The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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