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Mouse Anti-YY1AP1 Recombinant Antibody (2G7) (CBMAB-Y0081-LY)

This product is antibody recognizes YY1AP1. The antibody 2G7 immunoassay techniques such as: ELISA, WB, IF.
See all YY1AP1 antibodies
Published Data
Fig.1 Immunofluorescent cytochemical staining of endogenous YAP using anti-YAP antibody.
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Fig.2 Expression of YAP and phospho-YAP (Ser127) in three EMCA cell lines by western blotting.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2G7
Antibody Isotype
IgG2b, Κ
Application
ELISA, WB, IF

Basic Information

Immunogen
YY1AP1 full-length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
YY1 associated protein 1
Introduction
The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms. Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation.
Entrez Gene ID
55249
UniProt ID
Q9H869
Alternative Names
GRNG; HCCA1; HCCA2; YY1AP
Function
Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641).
Enhances transcription activation by YY1 (PubMed:14744866).
Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641).
Biological Process
Biological Process cell differentiation Source:UniProtKB1 Publication
Biological Process cell population proliferation Source:UniProtKB1 Publication
Biological Process regulation of cell cycle Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus
Nucleus, nucleoplasm
Nucleus, nucleolus
Involvement in disease
Grange syndrome (GRNG):
An autosomal recessive syndrome of stenosis or occlusion of multiple arteries, including renal, abdominal, cerebral and probably coronary arteries, congenital heart defects, brachydactyly, syndactyly, bone fragility, and learning disabilities.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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