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Mouse Anti-ZBTB1 Recombinant Antibody (CBWJZ-036) (CBMAB-Z0073-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJZ-036
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
zinc finger and BTB domain containing 1
Introduction
ZBTB1 (Zinc Finger And BTB Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is ZBTB2.
Entrez Gene ID
22890
UniProt ID
Q9Y2K1
Alternative Names
ZNF909
Function
Acts as a transcriptional repressor (PubMed:20797634).
Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167).
In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165).
Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).
Biological Process
Biological Process B cell differentiation Source:Ensembl
Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process cellular response to UV Source:UniProtKB1 Publication
Biological Process chromatin remodeling Source:UniProtKB1 Publication
Biological Process DNA repair Source:UniProtKB1 Publication
Biological Process innate immune response Source:UniProtKB-KW
Biological Process mRNA transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB2 Publications
Biological Process positive regulation of natural killer cell differentiation Source:UniProtKB
Biological Process positive regulation of pro-T cell differentiation Source:UniProtKB
Biological Process positive regulation of T cell differentiation Source:UniProtKB
Biological Process positive regulation of T cell mediated immunity Source:UniProtKB
Biological Process protein homooligomerization Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process T cell differentiation in thymus Source:Ensembl
Biological Process thymus development Source:UniProtKB
Biological Process translesion synthesis Source:UniProtKB1 Publication
Cellular Location
Nucleus
Nucleus, nucleoplasm
Localized in dot-like structures in the nucleus (PubMed:21706167).
Colocalized with SMRT in nuclear bodies (PubMed:20797634).
The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies(PubMed:20797634).
PTM
Sumoylated with SUMO2 at Lys-328 and to a lesser extent at Lys-265. Sumoylation inhibits its transcriptional repression activity and regulates its subcellular localization.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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