ZBTB1

Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).

Full Name

zinc finger and BTB domain containing 1

Function

Acts as a transcriptional repressor (PubMed:20797634).
Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167).
In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165).
Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).

Biological Process

Biological Process B cell differentiation Source:Ensembl
Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process cellular response to UV Source:UniProtKB1 Publication
Biological Process chromatin remodeling Source:UniProtKB1 Publication
Biological Process DNA repair Source:UniProtKB1 Publication
Biological Process innate immune response Source:UniProtKB-KW
Biological Process mRNA transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB2 Publications
Biological Process positive regulation of natural killer cell differentiation Source:UniProtKB
Biological Process positive regulation of pro-T cell differentiation Source:UniProtKB
Biological Process positive regulation of T cell differentiation Source:UniProtKB
Biological Process positive regulation of T cell mediated immunity Source:UniProtKB
Biological Process protein homooligomerization Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process T cell differentiation in thymus Source:Ensembl
Biological Process thymus development Source:UniProtKB
Biological Process translesion synthesis Source:UniProtKB1 Publication

Cellular Location

Nucleus
Nucleus, nucleoplasm
Localized in dot-like structures in the nucleus (PubMed:21706167).
Colocalized with SMRT in nuclear bodies (PubMed:20797634).
The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies(PubMed:20797634).

PTM

Sumoylated with SUMO2 at Lys-328 and to a lesser extent at Lys-265. Sumoylation inhibits its transcriptional repression activity and regulates its subcellular localization.