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Mouse Anti-ZC3H8 Recombinant Antibody (3G10) (CBMAB-Z0112-WJ)

This product is a mouse antibody that recognizes ZC3H8. The antibody 3G10 can be used for immunoassay techniques such as: WB.
See all ZC3H8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G10
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human ZC3H8 produced in E. coli.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL

Target

Full Name
zinc finger CCCH-type containing 8
Introduction
ZC3H8 (Zinc Finger CCCH-Type Containing 8) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA polymerase II transcribes snRNA genes. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZC3H6.
Entrez Gene ID
84524
UniProt ID
Q8N5P1
Alternative Names
Fliz1; ZC3HDC8
Function
Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity).
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780).
Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of T cell differentiation in thymus Source:UniProtKB1 Publication
Biological Process positive regulation of thymocyte apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase III Source:UniProtKB1 Publication
Biological Process response to antibiotic Source:UniProtKB1 Publication
Biological Process snRNA transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process snRNA transcription by RNA polymerase III Source:UniProtKB1 Publication
Biological Process T cell homeostasis Source:UniProtKB1 Publication
Cellular Location
Nucleus
Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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