Mouse Anti-ZC3H8 Recombinant Antibody (9F11) (CBMAB-Z0117-WJ)

Name: Mouse Anti-ZC3H8 Recombinant Antibody (9F11)
SKU: CBMAB-Z0117-WJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

9F11

Application

IHC-P

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

More Infomation

Target

Full Name

zinc finger CCCH-type containing 8

Introduction

ZC3H8 (Zinc Finger CCCH-Type Containing 8) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA polymerase II transcribes snRNA genes. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZC3H6.

Entrez Gene ID

84524

UniProt ID

Q8N5P1

Alternative Names

Fliz1; ZC3HDC8

Function

Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity).
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780).
Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

Biological Process

Biological Process apoptotic process Source:UniProtKB-KW
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of T cell differentiation in thymus Source:UniProtKB1 Publication
Biological Process positive regulation of thymocyte apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase III Source:UniProtKB1 Publication
Biological Process response to antibiotic Source:UniProtKB1 Publication
Biological Process snRNA transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process snRNA transcription by RNA polymerase III Source:UniProtKB1 Publication
Biological Process T cell homeostasis Source:UniProtKB1 Publication

Cellular Location

Nucleus
Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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