Mouse Anti-ZDHHC8 Recombinant Antibody (1G8) (CBMAB-Z0136-WJ)

Name: Mouse Anti-ZDHHC8 Recombinant Antibody (1G8)
SKU: CBMAB-Z0136-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1G8

Application

ELISA, WB

Immunogen

ZDHHC8 (AA1-42) full-length recombinant protein with GST tag. Immunogen sequence: MDRGTQGPHR PSDTACGLPD RVSPARLLLT NALPFTDPAG SL

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

More Infomation

Target

Full Name

zinc finger, DHHC-type containing 8

Introduction

ZDHHC8 (Zinc Finger DHHC-Type Containing 8) is a Protein Coding gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. Diseases associated with ZDHHC8 include Schizophrenia and Velocardiofacial Syndrome. Among its related pathways are Metabolism and Lipoprotein metabolism.

Entrez Gene ID

29801

UniProt ID

Q9ULC8

Alternative Names

DHHC8; ZNF378; ZDHHCL1

Function

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D2 dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity).
(Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell.

Biological Process

Biological Process high-density lipoprotein particle assembly Source:Reactome
Biological Process locomotory behavior Source:Ensembl
Biological Process peptidyl-L-cysteine S-palmitoylation Source:UniProtKB1 Publication
Biological Process positive regulation by host of viral process Source:UniProtKB1 Publication
Biological Process positive regulation of cholesterol efflux Source:UniProtKB1 Publication
Biological Process positive regulation of protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process protein palmitoylation Source:UniProtKB1 Publication

Cellular Location

Golgi apparatus membrane
Mitochondrion membrane

Topology

Cytoplasmic: 1-13
Helical: 14-34
Lumenal: 35-52
Helical: 53-73
Cytoplasmic: 74-148
Helical: 149-169
Lumenal: 170-190
Helical: 191-211
Cytoplasmic: 212-765

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-ZDHHC8 Recombinant Antibody (1C5) (CAT#: CBMAB-Z0135-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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