ZDHHC8

This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.

Full Name

zinc finger, DHHC-type containing 8

Function

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D2 dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity).
(Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell.

Biological Process

Biological Process high-density lipoprotein particle assembly Source:Reactome
Biological Process locomotory behavior Source:Ensembl
Biological Process peptidyl-L-cysteine S-palmitoylation Source:UniProtKB1 Publication
Biological Process positive regulation by host of viral process Source:UniProtKB1 Publication
Biological Process positive regulation of cholesterol efflux Source:UniProtKB1 Publication
Biological Process positive regulation of protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process protein palmitoylation Source:UniProtKB1 Publication

Cellular Location

Golgi apparatus membrane
Mitochondrion membrane

Topology

Cytoplasmic: 1-13
Helical: 14-34
Lumenal: 35-52
Helical: 53-73
Cytoplasmic: 74-148
Helical: 149-169
Lumenal: 170-190
Helical: 191-211
Cytoplasmic: 212-765