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Mouse Anti-ZFYVE1 Recombinant Antibody (4B2) (CBMAB-Z0241-WJ)

This product is a mouse antibody that recognizes ZFYVE1. The antibody 4B2 can be used for immunoassay techniques such as: ELISA, WB.
See all ZFYVE1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4B2
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ZFYVE1 (AA1-99) partial recombinant protein with GST tag. Immunogen sequence: MSAQTSPAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH RQERLRNHER IRLKPGHVPY CDLCKGLSGH LPGVRQRAIV RCQTCKINL
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
Zinc Finger FYVE-Type Containing 1
Introduction
ZFYVE1 (Zinc Finger FYVE-Type Containing 1) is a Protein Coding gene. Diseases associated with ZFYVE1 include Syndromic X-Linked Intellectual Disability Snyder Type. Among its related pathways are Autophagy - animal and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding and phosphatidylinositol-3,4-bisphosphate binding.
Entrez Gene ID
53349
UniProt ID
Q9HBF4
Alternative Names
SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172
Function
Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241).
Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241).
Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241).
Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955).
Biological Process
Biological Process cellular response to starvation Source:ParkinsonsUK-UCL1 Publication
Biological Process lipid droplet formation Source:UniProtKB1 Publication
Biological Process macroautophagy Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Golgi apparatus, Golgi stack
Golgi apparatus
Endoplasmic reticulum
Lipid droplet
Preautophagosomal structure
Mitochondrion
Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955).
Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386).
During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663).
Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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