Mouse Anti-ZFYVE1 Recombinant Antibody (4B2) (CBMAB-Z0241-WJ)

Name: Mouse Anti-ZFYVE1 Recombinant Antibody (4B2)
SKU: CBMAB-Z0241-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4B2

Application

ELISA, WB

Immunogen

ZFYVE1 (AA1-99) partial recombinant protein with GST tag. Immunogen sequence: MSAQTSPAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH RQERLRNHER IRLKPGHVPY CDLCKGLSGH LPGVRQRAIV RCQTCKINL

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

More Infomation

Target

Full Name

Zinc Finger FYVE-Type Containing 1

Introduction

ZFYVE1 (Zinc Finger FYVE-Type Containing 1) is a Protein Coding gene. Diseases associated with ZFYVE1 include Syndromic X-Linked Intellectual Disability Snyder Type. Among its related pathways are Autophagy - animal and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding and phosphatidylinositol-3,4-bisphosphate binding.

Entrez Gene ID

53349

UniProt ID

Q9HBF4

Alternative Names

SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172

Function

Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241).
Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241).
Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241).
Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955).

Biological Process

Biological Process cellular response to starvation Source:ParkinsonsUK-UCL1 Publication
Biological Process lipid droplet formation Source:UniProtKB1 Publication
Biological Process macroautophagy Source:ParkinsonsUK-UCL1 Publication

Cellular Location

Golgi apparatus, Golgi stack
Golgi apparatus
Endoplasmic reticulum
Lipid droplet
Preautophagosomal structure
Mitochondrion
Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955).
Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386).
During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663).
Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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