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Rabbit Anti-ZFYVE1 Recombinant Antibody (E9R6P) (CBMAB-CP3057-LY)

The product is antibody recognizes ZFYVE1. The antibody E9R6P immunoassay techniques such as: WB.
See all ZFYVE1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
E9R6P
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val451 of human DFCP1 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Zinc Finger FYVE-Type Containing 1
Introduction
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Entrez Gene ID
Human53349
Mouse217695
Rat299188
UniProt ID
HumanQ9HBF4
MouseQ810J8
RatD4A3T4
Function
Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241).
Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241).
Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241).
Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955).
Biological Process
Biological Process cellular response to starvation Source:ParkinsonsUK-UCL1 Publication
Biological Process lipid droplet formation Source:UniProtKB1 Publication
Biological Process macroautophagy Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Golgi apparatus, Golgi stack
Golgi apparatus
Endoplasmic reticulum
Lipid droplet
Preautophagosomal structure
Mitochondrion
Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955).
Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386).
During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663).
Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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