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Mouse Anti-RNF114 Recombinant Antibody (4G3-1A10) (CBMAB-A10168-LY)

The product is antibody recognizes ZNF313. The antibody 4G3-1A10 immunoassay techniques such as: WB, ELISA.
See all RNF114 antibodies
Published Data
Fig.1 RNF114 localizes to the cytoplasm.
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Fig.2 RNF114 expression is up-regulated by IFNa, IFNg and synthetic dsRNA.
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Fig.3 RNF114 positively regulates poly(I:C) induced IFNb production.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4G3-1A10
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
ZNF313 (AAH13695, 1 a.a. ~ 228 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ring Finger Protein 114
Entrez Gene ID
55905
UniProt ID
Q9Y508
Alternative Names
ZNF313
Function
E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885).
In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287).
Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885).
May promote the ubiquitination of TRAF6 as well (PubMed:28708287).
Acts also as a negative regulator of T-cell activation (PubMed:25165885).
Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885).
Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206).
This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis.
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatogenesisIEA:UniProtKB-KW
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
PTM
Autoubiquitinated. Polyubiquitinated in the presence of E2 enzymes UBE2D1, UBE2D2 and UBE2D3, but only monoubiquitinated in the presence of UBE2E1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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