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Mouse Anti-ZP2 Recombinant Antibody (2B9) (CBMAB-Z0715-WJ)

This product is a mouse antibody that recognizes ZP2. The antibody 2B9 can be used for immunoassay techniques such as: ELISA, WB.
See all ZP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B9
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ZP2 (AA400-509) partial recombinant protein with GST tag. Immunogen sequence: NSSCQPVFEA QSQGLVRFHI PLNGCGTRYK FEDDKVVYEN EIHALWTDFP PSKISRDSEF RMTVKCSYSR NDMLLNINVE SLTPPVASVK LGPFTLILQS YPDNSYQQPY
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
zona pellucida glycoprotein 2 (sperm receptor)
Introduction
ZP2 (Zona Pellucida Glycoprotein 2) is a Protein Coding gene. Diseases associated with ZP2 include Female Infertility Due To Zona Pellucida Defect and Acheiropody. Among its related pathways are Ovarian Infertility Genes and Reproduction. Gene Ontology (GO) annotations related to this gene include coreceptor activity and acrosin binding. An important paralog of this gene is ZP4.
Entrez Gene ID
7783
UniProt ID
Q05996
Alternative Names
ZPA; Zp-2
Function
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy (PubMed:29895852).
The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (PubMed:29895852).
Biological Process
Biological Process binding of sperm to zona pellucida Source:UniProtKBBy Similarity
Biological Process prevention of polyspermy Source:UniProtKBBy Similarity
Cellular Location
Processed zona pellucida sperm-binding protein 2
Zona pellucida
Cell membrane
Involvement in disease
Oocyte maturation defect 6 (OOMD6):
An autosomal recessive infertility disorder characterized by oocyte fertilization failure, due to defective sperm-binding to an abnormally thin zona pellucida in patient oocytes.
Topology
Extracellular: 39-716
Helical: 717-736
Cytoplasmic: 737-745
PTM
Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos.
N-glycosylated.
O-glycosylated; contains sulfate-substituted glycans.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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