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AXL Matched Antibody Pair (119) (APMAB-119LY)

This antibody pair set can be used for detecting and quantifying protein level of human AXL.
See all AXL antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-AXL monoclonal antibody, 100 ug
Detection Antibody
Anti-AXL Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Alternative Names
AXL Receptor Tyrosine Kinase; AXL Oncogene; EC 2.7.10.1; UFO; Tyrosine-Protein Kinase Receptor UFO; AXL Transforming Sequence/Gene;
Entrez Gene ID
558
UniProt ID
P30530

DeBerge, M., Glinton, K., Subramanian, M., Wilsbacher, L. D., Rothlin, C. V., Tabas, I., & Thorp, E. B. (2021). Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction. The Journal of clinical investigation, 131(6).

Brenig, R., Pop, O. T., Triantafyllou, E., Geng, A., Singanayagam, A., Perez-Shibayama, C., ... & Bernsmeier, C. (2020). Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis. Life science alliance, 3(1).

Namiki, K., Wongsirisin, P., Yokoyama, S., Sato, M., Rawangkan, A., Sakai, R., ... & Suganuma, M. (2020). (−)-Epigallocatechin gallate inhibits stemness and tumourigenicity stimulated by AXL receptor tyrosine kinase in human lung cancer cells. Scientific reports, 10(1), 1-11.

Lauter, M., Weber, A., & Torka, R. (2019). Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation. Cell Communication and Signaling, 17(1), 1-14.

Yan, S., Vandewalle, N., De Beule, N., Faict, S., Maes, K., De Bruyne, E., ... & De Veirman, K. (2019). AXL receptor tyrosine kinase as a therapeutic target in hematological malignancies: focus on multiple myeloma. Cancers, 11(11), 1727.

Zhang, G., Wang, M., Zhao, H., & Cui, W. (2018). Function of Axl receptor tyrosine kinase in non-small cell lung cancer. Oncology letters, 15(3), 2726-2734.

Badi, I., Mancinelli, L., Polizzotto, A., Ferri, D., Zeni, F., Burba, I., ... & Raucci, A. (2018). miR-34a promotes vascular smooth muscle cell calcification by downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase). Arteriosclerosis, thrombosis, and vascular biology, 38(9), 2079-2090.

Zhen, Y., Lee, I. J., Finkelman, F. D., & Shao, W. H. (2018). Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis. Journal of autoimmunity, 93, 37-44.

Kanlikilicer, P., Ozpolat, B., Aslan, B., Bayraktar, R., Gurbuz, N., Rodriguez-Aguayo, C., ... & Lopez-Berestein, G. (2017). Therapeutic targeting of AXL receptor tyrosine kinase inhibits tumor growth and intraperitoneal metastasis in ovarian cancer models. Molecular Therapy-Nucleic Acids, 9, 251-262.

Aguilera, T. A., & Giaccia, A. J. (2017). Molecular pathways: oncologic pathways and their role in T-cell exclusion and immune evasion—a new role for the AXL receptor tyrosine kinase. Clinical Cancer Research, 23(12), 2928-2933.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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