AXL Matched Antibody Pair (119) (APMAB-119LY)

Name: AXL Matched Antibody Pair (119)
SKU: APMAB-119LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-AXL monoclonal antibody, 100 ug

Detection Antibody

Anti-AXL Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Alternative Names

AXL Receptor Tyrosine Kinase; AXL Oncogene; EC 2.7.10.1; UFO; Tyrosine-Protein Kinase Receptor UFO; AXL Transforming Sequence/Gene;

Entrez Gene ID

558

UniProt ID

P30530

More Infomation

DeBerge, M., Glinton, K., Subramanian, M., Wilsbacher, L. D., Rothlin, C. V., Tabas, I., & Thorp, E. B. (2021). Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction. The Journal of clinical investigation, 131(6).

Brenig, R., Pop, O. T., Triantafyllou, E., Geng, A., Singanayagam, A., Perez-Shibayama, C., ... & Bernsmeier, C. (2020). Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis. Life science alliance, 3(1).

Namiki, K., Wongsirisin, P., Yokoyama, S., Sato, M., Rawangkan, A., Sakai, R., ... & Suganuma, M. (2020). (−)-Epigallocatechin gallate inhibits stemness and tumourigenicity stimulated by AXL receptor tyrosine kinase in human lung cancer cells. Scientific reports, 10(1), 1-11.

Lauter, M., Weber, A., & Torka, R. (2019). Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation. Cell Communication and Signaling, 17(1), 1-14.

Yan, S., Vandewalle, N., De Beule, N., Faict, S., Maes, K., De Bruyne, E., ... & De Veirman, K. (2019). AXL receptor tyrosine kinase as a therapeutic target in hematological malignancies: focus on multiple myeloma. Cancers, 11(11), 1727.

Zhang, G., Wang, M., Zhao, H., & Cui, W. (2018). Function of Axl receptor tyrosine kinase in non-small cell lung cancer. Oncology letters, 15(3), 2726-2734.

Badi, I., Mancinelli, L., Polizzotto, A., Ferri, D., Zeni, F., Burba, I., ... & Raucci, A. (2018). miR-34a promotes vascular smooth muscle cell calcification by downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase). Arteriosclerosis, thrombosis, and vascular biology, 38(9), 2079-2090.

Zhen, Y., Lee, I. J., Finkelman, F. D., & Shao, W. H. (2018). Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis. Journal of autoimmunity, 93, 37-44.

Kanlikilicer, P., Ozpolat, B., Aslan, B., Bayraktar, R., Gurbuz, N., Rodriguez-Aguayo, C., ... & Lopez-Berestein, G. (2017). Therapeutic targeting of AXL receptor tyrosine kinase inhibits tumor growth and intraperitoneal metastasis in ovarian cancer models. Molecular Therapy-Nucleic Acids, 9, 251-262.

Aguilera, T. A., & Giaccia, A. J. (2017). Molecular pathways: oncologic pathways and their role in T-cell exclusion and immune evasion—a new role for the AXL receptor tyrosine kinase. Clinical Cancer Research, 23(12), 2928-2933.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant AXL protein, ECD, His Tag (CAT#: V2LY-0526-LY2222)

Human Recombinant AXL protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY2223)

Human Recombinant AXL protein, ECD, Fc Tag (CAT#: V2LY-0526-LY2224)

Human Recombinant AXL, Active protein, GST Tag (CAT#: V2LY-0526-LY2225)

Human Recombinant AXL , Active protein, His Tag (CAT#: V2LY-0526-LY2226)

Human Recombinant AXL (R499C), Active protein, GST Tag (CAT#: V2LY-0526-LY2227)

Mouse Recombinant AXL protein, His & hFc Tag (CAT#: V2LY-0526-LY7832)

Mouse Recombinant AXL protein, His Tag (CAT#: V2LY-0526-LY7833)

Mouse Recombinant AXL protein, His Tag-1 (CAT#: V2LY-0526-LY7834)

Rat Recombinant AXL protein, ECD, His Tag (CAT#: V2LY-0526-LY9166)

Related Products

Human Recombinant AXL (R499C), Active protein, GST Tag (CAT#: V2LY-0526-LY2227)

Human Recombinant AXL protein, ECD, Fc Tag (CAT#: V2LY-0526-LY2224)

Mouse Anti-Axl Recombinant Antibody (CBYC-A910) (CAT#: CBMAB-A4239-YC)

Human Recombinant AXL , Active protein, His Tag (CAT#: V2LY-0526-LY2226)

Human Anti-AXL Recombinant Antibody (
6G10) (CAT#: V2LY-0725-LY1188)

Mouse Recombinant AXL protein, His & hFc Tag (CAT#: V2LY-0526-LY7832)

Human Recombinant AXL protein, ECD, His Tag (CAT#: V2LY-0526-LY2222)

Rat Anti-AXL Recombinant Antibody (10E7) (CAT#: CBMAB-A4230-YC)

Mouse Anti-AXL Recombinant Antibody (2N33) (CAT#: CBMAB-A4234-YC)

Mouse Anti-AXL Recombinant Antibody (CBT198) (CAT#: V2LY-0625-LY3716)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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