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B2M Matched Antibody Pair (121) (APMAB-121LY)

This antibody pair set can be used for detecting and quantifying protein level of human B2M.
See all B2M antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-B2M polyclonal antibody, 100 ug
Detection Antibody
Anti-B2M Mouse monoclonal, IgG2b antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]B2M (Beta-2-Microglobulin) is a Protein Coding gene. Diseases associated with B2M include Immunodeficiency 43 and Amyloidosis, Familial Visceral. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding.Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Alternative Names
Beta-2-Microglobulin; Beta Chain Of MHC Class I Molecules; Beta-2-Microglobin; IMD43;
Entrez Gene ID
567
UniProt ID
P61769

Shi, F., Sun, L., & Kaptoge, S. (2021). Association of beta-2-microglobulin and cardiovascular events and mortality: A systematic review and meta-analysis. Atherosclerosis.

Germano, G., Lu, S., Rospo, G., Lamba, S., Rousseau, B., Fanelli, S., ... & Bardelli, A. (2021). CD4 T cell dependent rejection of beta 2 microglobulin null mismatch repair deficient tumors. Cancer Discovery.

Tang, F., Zhao, Y. H., Zhang, Q., Wei, W., Tian, S. F., Li, C., ... & Li, Z. Q. (2021). Impact of beta‐2 microglobulin expression on the survival of glioma patients via modulating the tumor immune microenvironment. CNS Neuroscience & Therapeutics.

Liang, S., Li, Q., Lai, Q., Zhou, Y., Zhang, H., Chen, X., ... & Yang, X. (2021). Beta-2-Microglobulin is an Independent Risk Factor for Asymptomatic Carotid Atherosclerosis in Patients with Primary Aldosteronism. Journal of Atherosclerosis and Thrombosis, 62851.

Bento, L., Díaz‐López, A., Barranco, G., Martín‐Moreno, A. M., Baile, M., Martín, A., ... & Grupo Español de Linfomas y Trasplante Autólogo (GELTAMO). (2020). New prognosis score including absolute lymphocyte/monocyte ratio, red blood cell distribution width and beta‐2 microglobulin in patients with diffuse large B‐cell lymphoma treated with R‐CHOP: Spanish Lymphoma Group Experience (GELTAMO). British journal of haematology, 188(6), 888-897.

Snahnicanova, Z., Kasubova, I., Kalman, M., Grendar, M., Mikolajcik, P., Gabonova, E., ... & Lasabova, Z. (2020). Genetic and epigenetic analysis of the beta-2-microglobulin gene in microsatellite instable colorectal cancer. Clinical and experimental medicine, 20(1), 87-95.

Barrow, P., Richman, S. D., Wallace, A. J., Handley, K., Hutchins, G. G., Kerr, D., ... & Hill, J. (2019). Confirmation that somatic mutations of beta‐2 microglobulin correlate with a lack of recurrence in a subset of stage II mismatch repair deficient colorectal cancers from the QUASAR trial. Histopathology, 75(2), 236-246.

Zhang, C., Li, F., Long, T., Li, F., Peng, L., Xia, K., ... & Yang, T. (2019). Beta 2-microglobulin and the severity of coronary stenosis in patients with acute coronary syndrome. Heart, Lung and Circulation, 28(4), 575-582.

Clendenning, M., Huang, A., Jayasekara, H., Lorans, M., Preston, S., O’Callaghan, N., ... & Buchanan, D. D. (2018). Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas. Familial cancer, 17(1), 91-100.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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