BLNK Matched Antibody Pair (141) (APMAB-141LY)

Name: BLNK Matched Antibody Pair (141)
SKU: APMAB-141LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-BLNK monoclonal, IgG2a antibody, 100 ug

Detection Antibody

Anti-BLNK Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

Alternative Names

B Cell Linker; B-Cell Adapter Containing A SH2 Domain Protein; Src Homology [SH2] Domain-Containing Leukocyte Protein Of 65 KD; Src Homology 2 Domain-Containing Leukocyte Protein Of 65 KDa; B-Cell Adapter Containing A Src Homology 2 Domain Protein; B Cell Adaptor Containing SH2 Domain; Cytoplasmic Adapter Protein; B-Cell Activation; SLP-65;

Entrez Gene ID

29760

UniProt ID

Q8WV28

More Infomation

Zhang, P., Wang, Y., Qin, M., Li, D., Odhiambo, W. O., Yuan, M., ... & Ji, Y. (2021). Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells. Oncology reports, 45(2), 693-705.

Singh, M. V., Wong, T., & Dokun, A. O. (2021). BLNK/BTK: Novel Components in the NF-kappa B Pathways of Endothelial Cells in Diabetic Condition. Journal of the Endoc

Lee, J. H., Lee, J. H., Ahn, B. K., Paik, S. S., & Lee, K. H. (2020). Prognostic value of B-cell linker protein in colorectal cancer. Pathology-Research and Practice, 216(3), 152821.

Thomsen, E. A., Rovsing, A. B., Anderson, M. V., Due, H., Huang, J., Luo, Y., ... & Mikkelsen, J. G. (2020). Identification of BLNK and BTK as mediators of rituximab‐induced programmed cell death by CRISPR screens in GCB‐subtype diffuse large B‐cell lymphoma. Molecular oncology, 14(9), 1978-1997.

Xiao, B., Li, J., Zhou, M., Li, X., Huang, X., Hang, J., ... & Li, L. (2019). Structure and function of B-cell linker and its role in the development of B cell-related diseases. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 39(2), 253-256.

Mo, Z. Q., Wang, J. L., Han, R., Han, Q., Li, Y. W., Sun, H. Y., ... & Dan, X. M. (2018). Identification and functional analysis of grouper (Epinephelus coioides) B-cell linker protein BLNK. Fish & shellfish immunology, 81, 399-407.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant BLNK protein, TST Tag (CAT#: V2LY-0526-LY2362)

Human Recombinant BLNK protein, His Tag (CAT#: V2LY-0526-LY2363)

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Human Recombinant BLNK protein, His Tag (CAT#: V2LY-0526-LY2363)

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Rabbit Anti-BLNK Recombinant Antibody (CBYY-0626) (CAT#: CBMAB-0629-YY)

Mouse Anti-BLNK Recombinant Antibody (CBYY-0621) (CAT#: CBMAB-0624-YY)

Mouse Anti-BLNK Recombinant Antibody (CBT3392) (CAT#: V2LY-0625-LY2597)

Mouse Anti-BLNK Recombinant Antibody (CBYY-0623) (CAT#: CBMAB-0626-YY)

Human Recombinant BLNK protein, TST Tag (CAT#: V2LY-0526-LY2362)

Mouse Anti-BLNK Recombinant Antibody (CBYY-0622) (CAT#: CBMAB-0625-YY)

Mouse Anti-BLNK Recombinant Antibody (CBYY-0624) (CAT#: CBMAB-0627-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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