BLNK

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Full Name
B Cell Linker
Function
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Biological Process
B cell differentiation Source: UniProtKB
B cell receptor signaling pathway Source: UniProtKB
Humoral immune response Source: ProtInc
Inflammatory response Source: ProtInc
Intracellular signal transduction Source: UniProtKB
Positive regulation of gene expression Source: Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Cytoplasm; Cell membrane. BCR activation results in the translocation to membrane fraction.
Involvement in disease
Agammaglobulinemia 4, autosomal recessive (AGM4): A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
PTM
Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca2+ and MAPK signaling pathways.
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Anti-BLNK antibodies

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Mouse Anti-BLNK Recombinant Antibody (CBYY-0623) (CBMAB-0626-YY)

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Target: BLNK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-0623
Application*: WB, IP, IF, E, P
Datasheet SDS

Rabbit Anti-BLNK Recombinant Antibody (D8R3G) (CBMAB-CP0005-LY)

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Target: BLNK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D8R3G
Application*: WB
Datasheet SDS

Mouse Anti-BLNK Recombinant Antibody (1D7) (CBMAB-A0799-LY)

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Target: BLNK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 1D7
Application*: WB, E
Datasheet SDS

Rabbit Anti-BLNK Recombinant Antibody (CBYY-0626) (CBMAB-0629-YY)

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Target: BLNK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYY-0626
Application*: WB, IH
Datasheet SDS

Mouse Anti-BLNK Recombinant Antibody (CBYY-0624) (CBMAB-0627-YY)

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Target: BLNK
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYY-0624
Application*: WB
Datasheet SDS

Mouse Anti-BLNK Recombinant Antibody (CBYY-0622) (CBMAB-0625-YY)

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Target: BLNK
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYY-0622
Application*: WB
Datasheet SDS

Mouse Anti-BLNK Recombinant Antibody (CBYY-0621) (CBMAB-0624-YY)

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Target: BLNK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0621
Application*: E, WB, IF, IH, FC
Datasheet SDS

Mouse Anti-BLNK Recombinant Antibody (CBYY-0620) (CBMAB-0623-YY)

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Target: BLNK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-0620
Application*: E, WB, IP, IF
Datasheet SDS

Mouse Anti-BLNK Recombinant Antibody (CBT219) (V2LY-0625-LY3695)

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Target: BLNK
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBT219
Application*: WB, P, IF, IC, F, E
Datasheet SDS

Mouse Anti-BLNK Recombinant Antibody (CBT3392) (V2LY-0625-LY2597)

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Target: BLNK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT3392
Application*: WB, IH, IC, F
Datasheet SDS

Rabbit Anti-BLNK Recombinant Antibody (EG396) (CBMAB-EN444-LY)

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Target: BLNK (Phospho-Tyr84)
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG396
Application*: E
Datasheet SDS

Mouse Anti-BLNK Recombinant Antibody (5G9) (CBMAB-EN443-LY)

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Target: BLNK
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 5G9
Application*: WB, IH, IF, FC, E
Datasheet SDS

BLNK Matched Antibody Pair (141) (APMAB-141LY)

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Target: BLNK
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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