BLNK
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Full Name
B Cell Linker
Function
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Biological Process
B cell differentiation Source: UniProtKB
B cell receptor signaling pathway Source: UniProtKB
Humoral immune response Source: ProtInc
Inflammatory response Source: ProtInc
Intracellular signal transduction Source: UniProtKB
Positive regulation of gene expression Source: Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
B cell receptor signaling pathway Source: UniProtKB
Humoral immune response Source: ProtInc
Inflammatory response Source: ProtInc
Intracellular signal transduction Source: UniProtKB
Positive regulation of gene expression Source: Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Cytoplasm; Cell membrane. BCR activation results in the translocation to membrane fraction.
Involvement in disease
Agammaglobulinemia 4, autosomal recessive (AGM4): A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
PTM
Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca2+ and MAPK signaling pathways.
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Anti-BLNK antibodies
+ Filters
Target: BLNK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-0623
Application*: WB, IP, IF, E, P
Target: BLNK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D8R3G
Application*: WB
Target: BLNK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 1D7
Application*: WB, E
Target: BLNK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYY-0626
Application*: WB, IH
Target: BLNK
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYY-0624
Application*: WB
Target: BLNK
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYY-0622
Application*: WB
Target: BLNK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0621
Application*: E, WB, IF, IH, FC
Target: BLNK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-0620
Application*: E, WB, IP, IF
Target: BLNK
Sensitivity: 0.18 ng/mL
Detection Range: 0.2-60 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: BLNK
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-456
Tag: His Tag
Target: BLNK
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-456
Tag: TST Tag
Target: BLNK
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBT219
Application*: WB, P, IF, IC, F, E
Target: BLNK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT3392
Application*: WB, IH, IC, F
Target: BLNK (Phospho-Tyr84)
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG396
Application*: E
Target: BLNK
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 5G9
Application*: WB, IH, IF, FC, E
Target: BLNK
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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