Canine Recombinant CD2 protein, hFc Tag (V2LY-0526-LY1215)

Name: Canine Recombinant CD2 protein, hFc Tag
SKU: V2LY-0526-LY1215
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Canine

Tag

hFc Tag

Protein Construction

This product is Canine Recombinant CD2 protein, hFc Tag consist of Amino Acid: 1-204 and predicts a molecular mass of 47.6 kDa.

Molecule Mass

47.6 kDa

Sequence

Amino Acid: 1-204

Species

Canine

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, ETDA

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

CD2 Molecule

Alternative Names

CD2 Molecule; CD2 Antigen (P50), Sheep Red Blood Cell Receptor; T-Cell Surface Antigen T11/Leu-5; Erythrocyte Receptor; Rosette Receptor; LFA-3 Receptor; LFA-2;

Function

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Biological Process

Apoptotic process Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell surface receptor signaling pathway Source: UniProtKB
Heterotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Membrane raft polarization Source: UniProtKB
Natural killer cell activation Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Positive regulation of myeloid dendritic cell activation Source: UniProtKB
Positive regulation of tumor necrosis factor production Source: UniProtKB
Regulation of T cell differentiation Source: UniProtKB
T cell activation Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 25-209
Helical: 210-235
Cytoplasmic: 236-351

Demetriou, P., Abu-Shah, E., Valvo, S., McCuaig, S., Mayya, V., Kvalvaag, A., ... & Dustin, M. L. (2020). A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals. Nature immunology, 21(10), 1232-1243.

Polley, A., Orłowski, A., Danne, R., Gurtovenko, A. A., Bernardino de La Serna, J., Eggeling, C., ... & Vattulainen, I. (2017). Glycosylation and lipids working in concert direct CD2 ectodomain orientation and presentation. The journal of physical chemistry letters, 8(5), 1060-1066.

Han, J., Choi, Y. L., Kim, H., Choi, J. Y., Lee, S. K., Lee, J. E., ... & Shin, Y. K. (2017). MMP11 and CD2 as novel prognostic factors in hormone receptor-negative, HER2-positive breast cancer. Breast cancer research and treatment, 164(1), 41-56.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant CD2 protein, His Tag (CAT#: V2LY-0526-LY1216)

Cynomolgus Recombinant CD2 protein, hFc Tag (CAT#: V2LY-0526-LY1411)

Cynomolgus Recombinant CD2 protein, His Tag (CAT#: V2LY-0526-LY1412)

Cynomolgus Recombinant CD2 protein, His Tag-1 (CAT#: V2LY-0526-LY1413)

Human Recombinant CD2 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY2718)

Human Recombinant CD2 protein, ECD, hFc Tag-1 (CAT#: V2LY-0526-LY2719)

Human Recombinant CD2 protein, ECD, His Tag (CAT#: V2LY-0526-LY2720)

Human Recombinant CD2 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY2721)

Mouse Recombinant CD2 protein, His Tag (CAT#: V2LY-0526-LY7967)

Rat Recombinant CD2 protein, hFc Tag (CAT#: V2LY-0526-LY9216)

Related Products

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Mouse Anti-CD2 Recombinant Antibody (CBT2462) (CAT#: V2LY-0625-LY547)

Cynomolgus Recombinant CD2 protein, hFc Tag (CAT#: V2LY-0526-LY1411)

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Rat Recombinant CD2 protein, hFc Tag (CAT#: V2LY-0526-LY9216)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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