CD2

CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Penis Squamous Cell Carcinoma and Immune Defect Due To Absence Of Thymus. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and receptor activity.
Full Name
CD2 Molecule
Alternative Names
CD2 Molecule; CD2 Antigen (P50), Sheep Red Blood Cell Receptor; T-Cell Surface Antigen T11/Leu-5; Erythrocyte Receptor; Rosette Receptor; LFA-3 Receptor; LFA-2;
Function
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Biological Process
Apoptotic process Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell surface receptor signaling pathway Source: UniProtKB
Heterotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Membrane raft polarization Source: UniProtKB
Natural killer cell activation Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Positive regulation of myeloid dendritic cell activation Source: UniProtKB
Positive regulation of tumor necrosis factor production Source: UniProtKB
Regulation of T cell differentiation Source: UniProtKB
T cell activation Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 25-209
Helical: 210-235
Cytoplasmic: 236-351
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Anti-CD2 antibodies

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Mouse Anti-CD2 Recombinant Antibody (AG10) (V2LY-0524-LY17)

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Target: CD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: AG10
Application*: F, IH, WB
Datasheet SDS

Rat Anti-CD2 Recombinant Antibody (AG09) (V2LY-0524-LY16)

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Target: CD2
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: AG09
Application*: E, F, In Vivo
In Vivo Assay
Datasheet SDS

Mouse Anti-CD2 Recombinant Antibody (CBT2462) (V2LY-0625-LY547)

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Target: CD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT2462
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-CD2 Recombinant Antibody (CBT2790) (V2LY-0625-LY479)

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Target: CD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBT2790
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-CD2 Recombinant Antibody (CBT284) (V2LY-0625-LY3635)

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Target: CD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT284
Application*: P, IF
Datasheet SDS

Mouse Anti-CD2 Recombinant Antibody (EC106) (V2LY-0624-LY106)

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Target: CD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC106
Application*: P
Datasheet SDS

Mouse Anti-CD2 Recombinant Antibody (MT9-10) (CBMAB-C10075-LY)

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Target: CD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: MT9-10
Application*: IF, E, IP, WB, P
Datasheet SDS

Mouse Anti-CD2 Recombinant Antibody (OX-34) (CBMAB-C10060-LY)

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Target: CD2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: OX-34
Application*: WB, in vivo
In Vivo Assay
Datasheet SDS

Mouse Anti-CD2 Recombinant Antibody (HuLy-m1) (CBMAB-C0725-CQ)

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Target: CD2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: HuLy-m1
Application*: F, IP, WB
Datasheet SDS

Mouse Anti-CD2 Recombinant Antibody (CBFYC-0529) (CBMAB-C0582-FY)

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Target: CD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0529
Application*: IF, E, IP, WB
Datasheet SDS

Mouse Anti-CD2 Recombinant Antibody (CBFYC-0510) (CBMAB-C0561-FY)

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Target: CD2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0510
Application*: IF, E, IP, WB, P
Datasheet SDS

Mouse Anti-CD2 Recombinant Antibody (CBFYC-0394) (CBMAB-C0435-FY)

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Target: CD2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-0394
Application*: in vivo
In Vivo Assay
Datasheet SDS

Rat Anti-CD2 Recombinant Antibody (CBFYC-0313) (CBMAB-C0348-FY)

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Target: CD2
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-0313
Application*: E, IH, D, in vivo
In Vivo Assay
Datasheet SDS

Rabbit Anti-CD2 Recombinant Antibody (029) (CBMAB-C1693-LY)

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Target: CD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 029
Application*: E, P
Datasheet SDS

Rat Anti-CD2 Recombinant Antibody (12-15) (CBMAB-C0247-LY)

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Target: CD2
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 12-15
Application*: F
Datasheet SDS

Rabbit Anti-CD2 Recombinant Antibody (224) (CBMAB-C4417-LY)

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Target: CD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 224
Application*: E
Datasheet SDS

Rabbit Anti-CD2 Recombinant Antibody (118) (CBMAB-C0219-LY)

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Target: CD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 118
Application*: F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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