CD2

CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Penis Squamous Cell Carcinoma and Immune Defect Due To Absence Of Thymus. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and receptor activity.

CD2 Molecule

CD2 Molecule; CD2 Antigen (P50), Sheep Red Blood Cell Receptor; T-Cell Surface Antigen T11/Leu-5; Erythrocyte Receptor; Rosette Receptor; LFA-3 Receptor; LFA-2;

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Apoptotic process Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell surface receptor signaling pathway Source: UniProtKB
Heterotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Membrane raft polarization Source: UniProtKB
Natural killer cell activation Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Positive regulation of myeloid dendritic cell activation Source: UniProtKB
Positive regulation of tumor necrosis factor production Source: UniProtKB
Regulation of T cell differentiation Source: UniProtKB
T cell activation Source: UniProtKB

Cell membrane

Extracellular: 25-209
Helical: 210-235
Cytoplasmic: 236-351