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Mouse Anti-CD2 Recombinant Antibody (CBT2790) (V2LY-0625-LY479)


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Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBT2790
Antibody Isotype
IgG1
Application
WB, IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human CD2 (AA: 25-140) expressed in E. Coli.
Host Species
Mouse
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD2 Molecule
Entrez Gene ID
914
UniProt ID
P06729
Alternative Names
CD2 Molecule; CD2 Antigen (P50), Sheep Red Blood Cell Receptor; T-Cell Surface Antigen T11/Leu-5; Erythrocyte Receptor; Rosette Receptor; LFA-3 Receptor; LFA-2;
Function
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Biological Process
Apoptotic process Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell surface receptor signaling pathway Source: UniProtKB
Heterotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Membrane raft polarization Source: UniProtKB
Natural killer cell activation Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Positive regulation of myeloid dendritic cell activation Source: UniProtKB
Positive regulation of tumor necrosis factor production Source: UniProtKB
Regulation of T cell differentiation Source: UniProtKB
T cell activation Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 25-209
Helical: 210-235
Cytoplasmic: 236-351
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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